IL-37 ameliorates acetaminophen-induced acute liver injury by limiting MAPK/NFκB signaling-mediated liver inflammation

IL-37 ameliorates acetaminophen-induced acute liver injury by limiting MAPK/NFκB signaling-mediated liver inflammation

Abstract Acetaminophen (APAP) overdose is a common cause of drug-induced liver injury (DILI), which can lead to sterile inflammation and progress to acute liver failure and even death. However, there are currently limited therapeutic options available. Iinterleukin-37 (IL-37) is considered as an ant...

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Bibliographic Details
Main Authors: Juan Fu, Qiuhong Huang, Changfeng Sun, Shuyi Li, Qingsong Wang, Yunjian Sheng, Binfeng He, Zaichun You
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
IL-37
APAP
Liver injury
Sterile inflammation
Oxidative stress
Online Access:https://doi.org/10.1038/s41598-025-10764-x
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