Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?
Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2012/192503 |
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| _version_ | 1841524701578395648 |
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| author | Claus Desler Thomas Lau Hansen Jane Bruun Frederiksen Maiken Lise Marcker Keshav K. Singh Lene Juel Rasmussen |
| author_facet | Claus Desler Thomas Lau Hansen Jane Bruun Frederiksen Maiken Lise Marcker Keshav K. Singh Lene Juel Rasmussen |
| author_sort | Claus Desler |
| collection | DOAJ |
| description | Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues. During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines. Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies. |
| format | Article |
| id | doaj-art-f18b6f4ad49645d4ade38aa7e7b53ccf |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-f18b6f4ad49645d4ade38aa7e7b53ccf2025-02-03T05:47:36ZengWileyJournal of Aging Research2090-22042090-22122012-01-01201210.1155/2012/192503192503Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?Claus Desler0Thomas Lau Hansen1Jane Bruun Frederiksen2Maiken Lise Marcker3Keshav K. Singh4Lene Juel Rasmussen5Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, DenmarkCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, DenmarkCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, DenmarkCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, DenmarkDepartment of Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USACenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, DenmarkOxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues. During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines. Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies.http://dx.doi.org/10.1155/2012/192503 |
| spellingShingle | Claus Desler Thomas Lau Hansen Jane Bruun Frederiksen Maiken Lise Marcker Keshav K. Singh Lene Juel Rasmussen Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? Journal of Aging Research |
| title | Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? |
| title_full | Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? |
| title_fullStr | Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? |
| title_full_unstemmed | Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? |
| title_short | Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? |
| title_sort | is there a link between mitochondrial reserve respiratory capacity and aging |
| url | http://dx.doi.org/10.1155/2012/192503 |
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