Phenolic Profile and Antioxidant Capacity of Invasive <i>Solidago canadensis</i> L.: Potential Applications in Phytopharmacy
Canadian goldenrod <i>(Solidago canadensis</i> L.), an invasive plant in Europe, is known for its allelopathic activity and is rich in bioactive compounds like flavonoids and phenolic acids, with significant pharmacological potential. This study presents the LC-MS phenolic profiles of le...
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2024-12-01
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| author | Mirela Uzelac Božac Danijela Poljuha Slavica Dudaš Josipa Bilić Ivana Šola Maja Mikulič-Petkovšek Barbara Sladonja |
| author_facet | Mirela Uzelac Božac Danijela Poljuha Slavica Dudaš Josipa Bilić Ivana Šola Maja Mikulič-Petkovšek Barbara Sladonja |
| author_sort | Mirela Uzelac Božac |
| collection | DOAJ |
| description | Canadian goldenrod <i>(Solidago canadensis</i> L.), an invasive plant in Europe, is known for its allelopathic activity and is rich in bioactive compounds like flavonoids and phenolic acids, with significant pharmacological potential. This study presents the LC-MS phenolic profiles of leaf and flower extracts from <i>S. canadensis</i>, an invasive alien plant in the Istria region (Croatia). Total phenolics (TP) (45.78–110.68 mg GAE/g DW) and non-flavonoids (TNF) (28.38–72.20 mg GAE/g DW) were found to be more abundant in ethanolic than in methanolic extracts. The antioxidant capacity (AC), as measured by ABTS, DPPH, and FRAP assays, was higher in flower extracts compared to leaf extracts. A non-targeted metabolomics approach was used, and 41 phenolic compounds in leaves and 36 in flowers were identified, with hydroxycinnamic acids and flavonols being the most abundant. 5-caffeoylquinic acid was quantitatively predominant in the leaf extracts, while quercetin-3-rutinoside dominated the flower extracts. Five leaf-specific compounds were identified (dicaffeoylquinic acid 2, 4-<i>p</i>-coumaroylquinic acid 1, <i>p</i>-hydroxybenzoic acid, quercetin-3-rhamnoside, and quercetin acetylhexoside 1), suggesting targeted extraction for different pharmacological applications. This study highlights the therapeutic potential of <i>S. canadensis</i> and underscores the need for further research on the bioavailability, efficacy, and safety of its compounds, potentially transforming this ecological threat into a valuable resource for drug development. |
| format | Article |
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| institution | Kabale University |
| issn | 2223-7747 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj-art-f17b5bea0a4a41c384db4ef01d91e3462025-01-10T13:19:34ZengMDPI AGPlants2223-77472024-12-011414410.3390/plants14010044Phenolic Profile and Antioxidant Capacity of Invasive <i>Solidago canadensis</i> L.: Potential Applications in PhytopharmacyMirela Uzelac Božac0Danijela Poljuha1Slavica Dudaš2Josipa Bilić3Ivana Šola4Maja Mikulič-Petkovšek5Barbara Sladonja6Department of Agriculture and Nutrition, Institute of Agriculture and Tourism, Karla Huguesa 8, 52440 Poreč, CroatiaDepartment of Agriculture and Nutrition, Institute of Agriculture and Tourism, Karla Huguesa 8, 52440 Poreč, CroatiaAgricultural Department, Polytechnic of Rijeka, Karla Huguesa 6, 52440 Poreč, CroatiaMETRIS Research Centre, Istrian University of Applied Sciences, Zagrebačka 30, 52100 Pula, CroatiaDepartment of Biology, Faculty of Science, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Agronomy, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, SloveniaDepartment of Agriculture and Nutrition, Institute of Agriculture and Tourism, Karla Huguesa 8, 52440 Poreč, CroatiaCanadian goldenrod <i>(Solidago canadensis</i> L.), an invasive plant in Europe, is known for its allelopathic activity and is rich in bioactive compounds like flavonoids and phenolic acids, with significant pharmacological potential. This study presents the LC-MS phenolic profiles of leaf and flower extracts from <i>S. canadensis</i>, an invasive alien plant in the Istria region (Croatia). Total phenolics (TP) (45.78–110.68 mg GAE/g DW) and non-flavonoids (TNF) (28.38–72.20 mg GAE/g DW) were found to be more abundant in ethanolic than in methanolic extracts. The antioxidant capacity (AC), as measured by ABTS, DPPH, and FRAP assays, was higher in flower extracts compared to leaf extracts. A non-targeted metabolomics approach was used, and 41 phenolic compounds in leaves and 36 in flowers were identified, with hydroxycinnamic acids and flavonols being the most abundant. 5-caffeoylquinic acid was quantitatively predominant in the leaf extracts, while quercetin-3-rutinoside dominated the flower extracts. Five leaf-specific compounds were identified (dicaffeoylquinic acid 2, 4-<i>p</i>-coumaroylquinic acid 1, <i>p</i>-hydroxybenzoic acid, quercetin-3-rhamnoside, and quercetin acetylhexoside 1), suggesting targeted extraction for different pharmacological applications. This study highlights the therapeutic potential of <i>S. canadensis</i> and underscores the need for further research on the bioavailability, efficacy, and safety of its compounds, potentially transforming this ecological threat into a valuable resource for drug development.https://www.mdpi.com/2223-7747/14/1/44Canadian goldenrodflowerinvasive plantsleafplant extracts |
| spellingShingle | Mirela Uzelac Božac Danijela Poljuha Slavica Dudaš Josipa Bilić Ivana Šola Maja Mikulič-Petkovšek Barbara Sladonja Phenolic Profile and Antioxidant Capacity of Invasive <i>Solidago canadensis</i> L.: Potential Applications in Phytopharmacy Plants Canadian goldenrod flower invasive plants leaf plant extracts |
| title | Phenolic Profile and Antioxidant Capacity of Invasive <i>Solidago canadensis</i> L.: Potential Applications in Phytopharmacy |
| title_full | Phenolic Profile and Antioxidant Capacity of Invasive <i>Solidago canadensis</i> L.: Potential Applications in Phytopharmacy |
| title_fullStr | Phenolic Profile and Antioxidant Capacity of Invasive <i>Solidago canadensis</i> L.: Potential Applications in Phytopharmacy |
| title_full_unstemmed | Phenolic Profile and Antioxidant Capacity of Invasive <i>Solidago canadensis</i> L.: Potential Applications in Phytopharmacy |
| title_short | Phenolic Profile and Antioxidant Capacity of Invasive <i>Solidago canadensis</i> L.: Potential Applications in Phytopharmacy |
| title_sort | phenolic profile and antioxidant capacity of invasive i solidago canadensis i l potential applications in phytopharmacy |
| topic | Canadian goldenrod flower invasive plants leaf plant extracts |
| url | https://www.mdpi.com/2223-7747/14/1/44 |
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