Multi-omics analysis for identifying cell-type-specific and bulk-level druggable targets in Alzheimer’s disease

Multi-omics analysis for identifying cell-type-specific and bulk-level druggable targets in Alzheimer’s disease

Abstract Background Analyzing disease-linked genetic variants via expression quantitative trait loci (eQTLs) helps identify potential disease-causing genes. Previous research prioritized genes by integrating Genome-Wide Association Study (GWAS) results with tissue-level eQTLs. Recent studies have ex...

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Main Authors: Shiwei Liu, Minyoung Cho, Yen-Ning Huang, Tamina Park, Soumilee Chaudhuri, Thea J. Rosewood, Paula J. Bice, Dongjun Chung, David A. Bennett, Nilüfer Ertekin-Taner, Andrew J. Saykin, Kwangsik Nho
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Causal genes
eQTL
Alzheimer’s disease
GWAS
SNP
Genetic variant
Online Access:https://doi.org/10.1186/s12967-025-06739-1
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https://doi.org/10.1186/s12967-025-06739-1

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