25 years of Drosophila “Sleep genes”
The field of Drosophila sleep research, which began 25 years ago, has identified more than 200 genes influencing sleep. In this review, I summarize the foundation of the field and the growing list of genes implicated in sleep regulation. I compare the genetic methods used to identify genes governing...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Fly |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19336934.2025.2502180 |
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| _version_ | 1849315323055964160 |
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| author | Orie Thomas Shafer |
| author_facet | Orie Thomas Shafer |
| author_sort | Orie Thomas Shafer |
| collection | DOAJ |
| description | The field of Drosophila sleep research, which began 25 years ago, has identified more than 200 genes influencing sleep. In this review, I summarize the foundation of the field and the growing list of genes implicated in sleep regulation. I compare the genetic methods used to identify genes governing sleep and circadian rhythms and the distinct outcomes of screens for genes regulating these two highly related processes. Finally, I discuss the ~ 200 sleep-regulating genes of Drosophila in the context of recent developments in the field and voice reasons for scepticism regarding the relevance of these genes to the homoeostatic regulation of sleep. Finally, I speculate on the future promise of the fly model system for revealing conserved molecular mechanisms of sleep homoeostasis. |
| format | Article |
| id | doaj-art-f159c781a38f4c04bc4d5b0dd8c534e7 |
| institution | Kabale University |
| issn | 1933-6934 1933-6942 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Fly |
| spelling | doaj-art-f159c781a38f4c04bc4d5b0dd8c534e72025-08-20T03:52:10ZengTaylor & Francis GroupFly1933-69341933-69422025-12-0119110.1080/19336934.2025.250218025 years of Drosophila “Sleep genes”Orie Thomas Shafer0Gill Institute for Neuroscience and Department of Biology, Indiana University in Bloomington, Bloomington, IN, USAThe field of Drosophila sleep research, which began 25 years ago, has identified more than 200 genes influencing sleep. In this review, I summarize the foundation of the field and the growing list of genes implicated in sleep regulation. I compare the genetic methods used to identify genes governing sleep and circadian rhythms and the distinct outcomes of screens for genes regulating these two highly related processes. Finally, I discuss the ~ 200 sleep-regulating genes of Drosophila in the context of recent developments in the field and voice reasons for scepticism regarding the relevance of these genes to the homoeostatic regulation of sleep. Finally, I speculate on the future promise of the fly model system for revealing conserved molecular mechanisms of sleep homoeostasis.https://www.tandfonline.com/doi/10.1080/19336934.2025.2502180SleephomeostasisDrosophilaforward genetic screensreverse genetics |
| spellingShingle | Orie Thomas Shafer 25 years of Drosophila “Sleep genes” Fly Sleep homeostasis Drosophila forward genetic screens reverse genetics |
| title | 25 years of Drosophila “Sleep genes” |
| title_full | 25 years of Drosophila “Sleep genes” |
| title_fullStr | 25 years of Drosophila “Sleep genes” |
| title_full_unstemmed | 25 years of Drosophila “Sleep genes” |
| title_short | 25 years of Drosophila “Sleep genes” |
| title_sort | 25 years of drosophila sleep genes |
| topic | Sleep homeostasis Drosophila forward genetic screens reverse genetics |
| url | https://www.tandfonline.com/doi/10.1080/19336934.2025.2502180 |
| work_keys_str_mv | AT oriethomasshafer 25yearsofdrosophilasleepgenes |