AP1 Transcription Factors in Epidermal Differentiation and Skin Cancer
AP1 (jun/fos) transcription factors (c-jun, junB, junD, c-fos, FosB, Fra-1, and Fra-2) are key regulators of epidermal keratinocyte survival and differentiation and important drivers of cancer development. Understanding the role of these factors in epidermis is complicated by the fact that each prot...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/537028 |
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| _version_ | 1841524501980905472 |
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| author | Richard L. Eckert Gautam Adhikary Christina A. Young Ralph Jans James F. Crish Wen Xu Ellen A. Rorke |
| author_facet | Richard L. Eckert Gautam Adhikary Christina A. Young Ralph Jans James F. Crish Wen Xu Ellen A. Rorke |
| author_sort | Richard L. Eckert |
| collection | DOAJ |
| description | AP1 (jun/fos) transcription factors (c-jun, junB, junD, c-fos, FosB, Fra-1, and Fra-2) are key regulators of epidermal keratinocyte survival and differentiation and important drivers of cancer development. Understanding the role of these factors in epidermis is complicated by the fact that each protein is expressed, at different levels, in multiple cells layers in differentiating epidermis, and because AP1 transcription factors regulate competing processes (i.e., proliferation, apoptosis, and differentiation). Various in vivo genetic approaches have been used to study these proteins including targeted and conditional knockdown, overexpression, and expression of dominant-negative inactivating AP1 transcription factors in epidermis. Taken together, these studies suggest that individual AP1 transcription factors have different functions in the epidermis and in cancer development and that altering AP1 transcription factor function in the basal versus suprabasal layers differentially influences the epidermal differentiation response and disease and cancer development. |
| format | Article |
| id | doaj-art-f143e49a7dba48b9b21a503214da0e09 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-f143e49a7dba48b9b21a503214da0e092025-02-03T05:53:13ZengWileyJournal of Skin Cancer2090-29052090-29132013-01-01201310.1155/2013/537028537028AP1 Transcription Factors in Epidermal Differentiation and Skin CancerRichard L. Eckert0Gautam Adhikary1Christina A. Young2Ralph Jans3James F. Crish4Wen Xu5Ellen A. Rorke6Department of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, 108 North Greene Street, Rm 103, Baltimore, MD 21201, USADepartment of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, 108 North Greene Street, Rm 103, Baltimore, MD 21201, USADepartment of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, 108 North Greene Street, Rm 103, Baltimore, MD 21201, USADepartment of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, 108 North Greene Street, Rm 103, Baltimore, MD 21201, USADepartment of Cell Biology, Cleveland Clinic Foundation, Cleveland, OH 44106, USADepartment of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, 108 North Greene Street, Rm 103, Baltimore, MD 21201, USADepartment of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USAAP1 (jun/fos) transcription factors (c-jun, junB, junD, c-fos, FosB, Fra-1, and Fra-2) are key regulators of epidermal keratinocyte survival and differentiation and important drivers of cancer development. Understanding the role of these factors in epidermis is complicated by the fact that each protein is expressed, at different levels, in multiple cells layers in differentiating epidermis, and because AP1 transcription factors regulate competing processes (i.e., proliferation, apoptosis, and differentiation). Various in vivo genetic approaches have been used to study these proteins including targeted and conditional knockdown, overexpression, and expression of dominant-negative inactivating AP1 transcription factors in epidermis. Taken together, these studies suggest that individual AP1 transcription factors have different functions in the epidermis and in cancer development and that altering AP1 transcription factor function in the basal versus suprabasal layers differentially influences the epidermal differentiation response and disease and cancer development.http://dx.doi.org/10.1155/2013/537028 |
| spellingShingle | Richard L. Eckert Gautam Adhikary Christina A. Young Ralph Jans James F. Crish Wen Xu Ellen A. Rorke AP1 Transcription Factors in Epidermal Differentiation and Skin Cancer Journal of Skin Cancer |
| title | AP1 Transcription Factors in Epidermal Differentiation and Skin Cancer |
| title_full | AP1 Transcription Factors in Epidermal Differentiation and Skin Cancer |
| title_fullStr | AP1 Transcription Factors in Epidermal Differentiation and Skin Cancer |
| title_full_unstemmed | AP1 Transcription Factors in Epidermal Differentiation and Skin Cancer |
| title_short | AP1 Transcription Factors in Epidermal Differentiation and Skin Cancer |
| title_sort | ap1 transcription factors in epidermal differentiation and skin cancer |
| url | http://dx.doi.org/10.1155/2013/537028 |
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