Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth

Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth

Abstract Background The colon and rectum are highly innervated, with neural components within the tumor microenvironment playing a significant role in colorectal cancer (CRC) progression. While perineural invasion (PNI) is associated with poor prognosis in CRC, the impact of nerve density and diamet...

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Bibliographic Details
Main Authors: Hao Wang, Ruixue Huo, Kexin He, Weihan Li, Yuan Gao, Wei He, Minhao Yu, Shu-Heng Jiang, Junli Xue
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
Perineural invasion
Nerve density
Prognosis
Tumor denervation
Neural remodeling
Online Access:https://doi.org/10.1186/s12967-025-06104-2
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