POCOP-Ni(II) pincer compounds derived from phloroglucinol. Cytotoxic and antioxidant evaluation
POCOP-Ni(II) pincer compounds have primarily been explored as catalysts, but their potential biological activity has been scarcely studied. To address this gap, we evaluated the anticancer and antioxidant potential of four POCOP-Ni(II) complexes derived from phloroglucinol. A comprehensive supramole...
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| Format: | Article |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2024.1483999/full |
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| author | Andrés Amaya-Flórez Juan S. Serrano-García Jordi Ruiz-Galindo Antonino Arenaza-Corona J. Antonio Cruz-Navarro Adrian L. Orjuela Jorge Alí-Torres Marcos Flores-Alamo Patricia Cano-Sanchez Viviana Reyes-Márquez David Morales-Morales |
| author_facet | Andrés Amaya-Flórez Juan S. Serrano-García Jordi Ruiz-Galindo Antonino Arenaza-Corona J. Antonio Cruz-Navarro Adrian L. Orjuela Jorge Alí-Torres Marcos Flores-Alamo Patricia Cano-Sanchez Viviana Reyes-Márquez David Morales-Morales |
| author_sort | Andrés Amaya-Flórez |
| collection | DOAJ |
| description | POCOP-Ni(II) pincer compounds have primarily been explored as catalysts, but their potential biological activity has been scarcely studied. To address this gap, we evaluated the anticancer and antioxidant potential of four POCOP-Ni(II) complexes derived from phloroglucinol. A comprehensive supramolecular analysis, based on single-crystal X-ray diffraction (DRX) structures, was conducted using Hirshfeld surfaces and non-covalent interaction analysis. The cytotoxicity of all complexes was systematically assessed against various cancerous cell lines, as well as a non-cancerous cell line (COS-7). The results revealed that complexes 1b and 1c exhibited remarkable antiproliferative activity, with IC50 values ranging from 2.43 to 7.85 μM against cancerous cell lines U251, K562, HCT-15, MCF-7, and SK-LU-1. To further elucidate their mechanism of action, a competitive fluorescence displacement assay with ethidium bromide (EB) suggested that these complexes possess the ability to intercalate with DNA. This multifaceted investigation not only enhances our understanding of the biological potential of POCOP-Ni complexes but also provides valuable insights into their structural features and interactions, paving the way for future exploration in both catalytic and therapeutic domains. |
| format | Article |
| id | doaj-art-f122df3ad1cc451486cb4e3ce0144ad0 |
| institution | Kabale University |
| issn | 2296-2646 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj-art-f122df3ad1cc451486cb4e3ce0144ad02024-11-20T04:50:01ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462024-11-011210.3389/fchem.2024.14839991483999POCOP-Ni(II) pincer compounds derived from phloroglucinol. Cytotoxic and antioxidant evaluationAndrés Amaya-Flórez0Juan S. Serrano-García1Jordi Ruiz-Galindo2Antonino Arenaza-Corona3J. Antonio Cruz-Navarro4Adrian L. Orjuela5Jorge Alí-Torres6Marcos Flores-Alamo7Patricia Cano-Sanchez8Viviana Reyes-Márquez9David Morales-Morales10Instituto de Química, Universidad Nacional Autónoma de México, Ciudad de México, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Ciudad de México, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Ciudad de México, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Ciudad de México, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Ciudad de México, MexicoDepartamento de Química, Universidad Nacional de Colombia-Sede Bogotá, Bogotá, ColombiaDepartamento de Química, Universidad Nacional de Colombia-Sede Bogotá, Bogotá, ColombiaFacultad de Química, División de Estudios de Posgrado, Universidad Nacional Autónoma de México, Mexico city, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Ciudad de México, MexicoDepartamento de Ciencias Químico-Biológicas, Universidad de Sonora, Hermosillo, Sonora, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Ciudad de México, MexicoPOCOP-Ni(II) pincer compounds have primarily been explored as catalysts, but their potential biological activity has been scarcely studied. To address this gap, we evaluated the anticancer and antioxidant potential of four POCOP-Ni(II) complexes derived from phloroglucinol. A comprehensive supramolecular analysis, based on single-crystal X-ray diffraction (DRX) structures, was conducted using Hirshfeld surfaces and non-covalent interaction analysis. The cytotoxicity of all complexes was systematically assessed against various cancerous cell lines, as well as a non-cancerous cell line (COS-7). The results revealed that complexes 1b and 1c exhibited remarkable antiproliferative activity, with IC50 values ranging from 2.43 to 7.85 μM against cancerous cell lines U251, K562, HCT-15, MCF-7, and SK-LU-1. To further elucidate their mechanism of action, a competitive fluorescence displacement assay with ethidium bromide (EB) suggested that these complexes possess the ability to intercalate with DNA. This multifaceted investigation not only enhances our understanding of the biological potential of POCOP-Ni complexes but also provides valuable insights into their structural features and interactions, paving the way for future exploration in both catalytic and therapeutic domains.https://www.frontiersin.org/articles/10.3389/fchem.2024.1483999/fullcytotoxic evaluationantioxidant propertiespincer compoundsPOCOP-Ni(II) complexesmetallopharmaceuticals |
| spellingShingle | Andrés Amaya-Flórez Juan S. Serrano-García Jordi Ruiz-Galindo Antonino Arenaza-Corona J. Antonio Cruz-Navarro Adrian L. Orjuela Jorge Alí-Torres Marcos Flores-Alamo Patricia Cano-Sanchez Viviana Reyes-Márquez David Morales-Morales POCOP-Ni(II) pincer compounds derived from phloroglucinol. Cytotoxic and antioxidant evaluation Frontiers in Chemistry cytotoxic evaluation antioxidant properties pincer compounds POCOP-Ni(II) complexes metallopharmaceuticals |
| title | POCOP-Ni(II) pincer compounds derived from phloroglucinol. Cytotoxic and antioxidant evaluation |
| title_full | POCOP-Ni(II) pincer compounds derived from phloroglucinol. Cytotoxic and antioxidant evaluation |
| title_fullStr | POCOP-Ni(II) pincer compounds derived from phloroglucinol. Cytotoxic and antioxidant evaluation |
| title_full_unstemmed | POCOP-Ni(II) pincer compounds derived from phloroglucinol. Cytotoxic and antioxidant evaluation |
| title_short | POCOP-Ni(II) pincer compounds derived from phloroglucinol. Cytotoxic and antioxidant evaluation |
| title_sort | pocop ni ii pincer compounds derived from phloroglucinol cytotoxic and antioxidant evaluation |
| topic | cytotoxic evaluation antioxidant properties pincer compounds POCOP-Ni(II) complexes metallopharmaceuticals |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2024.1483999/full |
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