Genomic analysis of Plasmodium vivax field isolates circulating in sub-Saharan Africa
Abstract Plasmodium vivax malaria is a major public health problem outside sub-Saharan Africa. However, an increasing number of P. vivax infections in Duffy-negative individuals has been reported across Africa in recent years, raising concerns that the parasites may have evolved alternative pathways...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08276-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract Plasmodium vivax malaria is a major public health problem outside sub-Saharan Africa. However, an increasing number of P. vivax infections in Duffy-negative individuals has been reported across Africa in recent years, raising concerns that the parasites may have evolved alternative pathways to invade reticulocyte and overcome Duffy-negativity. Here, we investigated the global genetic structure and diversity of sub-Saharan African P. vivax populations, exploring possible molecular signatures of adaptation to Duffy-negative hosts. We analyzed 204 previously published P. vivax genome sequences from Africa, Southeast Asia, the Pacific Coral Triangle, and South America and generated whole-genome sequences of 133 P. vivax field isolates collected from 10 sub-Saharan African countries. Our analysis revealed four distinct geographic clusters, with clear contrasts between East/West Africa and the Indian Ocean populations. Despite the limited number of interpretable sequences from Duffy-negative individuals - attributable to low parasitemia - and the lack of clear evidence of selective pressure acting on invasion-related genes of the P. vivax parasite populations circulating in sub-Saharan Africa, our study offers valuable insights into the genetic diversity of P. vivax and lays the groundwork for future research exploring parasite adaptation to Duffy-negative hosts. |
|---|---|
| ISSN: | 2399-3642 |