Carbapenemases producing gram-negative bacteria surveillance in Latin America and the caribbean: a retrospective observational study from 2015 to 2020Research in context
Summary: Background: The rise of multidrug-resistant (MDR) bacteria represents a public health threat, with carbapenem resistance exacerbating this challenge. This study investigates carbapenemase-producing bacteria (CPB) across the Latin America and the Caribbean (LAC) region. Methods: A retrospec...
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Elsevier
2025-09-01
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| Series: | The Lancet Regional Health. Americas |
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| author | Marcelo Pillonetto Priscila Lamb Wink Roberto G. Melano María Antonieta Jiménez-Pearson Nancy Lorena Melgarejo Touchet Sandra Yamile Saavedra Rojas Debora N.O. Kulek Andre Luiz Abreu Renata Tigulini Peral Rogerio Miorando Hatim Sati Genara Romero Thomas Marcelo Galas Pilar Ramon Pardo Carlos R.V. Kiffer Ana Paula D'Alincourt Carvalho Assef Marinonio Ana Sílvia Scavacini Costa-Nobre Daniela Testoni Gonçalves Geiziane Aparecida Jesus Ronaldo de Rezende Thais F. T Hormazabal Juan Carlos Araya Pamela Ovalle María Victoria Duarte Carolina Álvarez Tábata Elizondo Hernández Priscilla Baltodano Illnait María Teresa Quiñones Dianelys Salazar Carolina Satan Román Karla Grande Miguel Boza Maria Luna Herrera Andrés Herrera Carmen Julia Mazariegos Acuña Julissa Maria Avila Lira Lissette Carolina Sandoval Busignani Sofía Brítez Mariel Gavilan Ronnie Flores-Leon Diana Lopez Mariana Caiata Leticia Palmar Kerlin Vanessa Marcano Noguera Carmen Isaura Ugarte Torrico Elizabeth Copa Helen |
| author_facet | Marcelo Pillonetto Priscila Lamb Wink Roberto G. Melano María Antonieta Jiménez-Pearson Nancy Lorena Melgarejo Touchet Sandra Yamile Saavedra Rojas Debora N.O. Kulek Andre Luiz Abreu Renata Tigulini Peral Rogerio Miorando Hatim Sati Genara Romero Thomas Marcelo Galas Pilar Ramon Pardo Carlos R.V. Kiffer Ana Paula D'Alincourt Carvalho Assef Marinonio Ana Sílvia Scavacini Costa-Nobre Daniela Testoni Gonçalves Geiziane Aparecida Jesus Ronaldo de Rezende Thais F. T Hormazabal Juan Carlos Araya Pamela Ovalle María Victoria Duarte Carolina Álvarez Tábata Elizondo Hernández Priscilla Baltodano Illnait María Teresa Quiñones Dianelys Salazar Carolina Satan Román Karla Grande Miguel Boza Maria Luna Herrera Andrés Herrera Carmen Julia Mazariegos Acuña Julissa Maria Avila Lira Lissette Carolina Sandoval Busignani Sofía Brítez Mariel Gavilan Ronnie Flores-Leon Diana Lopez Mariana Caiata Leticia Palmar Kerlin Vanessa Marcano Noguera Carmen Isaura Ugarte Torrico Elizabeth Copa Helen |
| author_sort | Marcelo Pillonetto |
| collection | DOAJ |
| description | Summary: Background: The rise of multidrug-resistant (MDR) bacteria represents a public health threat, with carbapenem resistance exacerbating this challenge. This study investigates carbapenemase-producing bacteria (CPB) across the Latin America and the Caribbean (LAC) region. Methods: A retrospective observational study was conducted across 12 LAC countries from 2015 to 2020. A total of 58,909 isolates were analyzed utilizing polymerase chain reaction (PCR) to detect key carbapenemases in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii complex (ABC). Findings: 47,804/58,909 (81.14%) carbapenemases were identified, with Brazil accounting for 73% of these. The majority were reported in carbapenem-resistant Enterobacterales–CRE (65.33%; 31,230/47,804), followed by carbapenem-resistant ABC-CRAB (22.05%; 10,542/47,804), and carbapenem-resistant P. aeruginosa–CRPA (6050/47,804; 12.66%). Among CRE, blaKPC was the most detected gene (78.67%; 24,569/31,230), with Klebsiella pneumoniae being the most commonly associated species (75.9%). A relevant upward trend in blaNDM was observed. CRPA exhibited diverse profiles, with blaVIM (47.64%) being the most common. In CRAB, blaOXA-23 was found in 88.80% (9361/10,542) of isolates. Carbapenemase co-production was detected in 2.60% (1190/47,804) of isolates, with CRPA blaIMP + blaVIM being the most frequent. Interpretation: This study highlights a high prevalence of CPB in LAC, with a stable trend in blaKPC but a rising trend in blaNDM. These findings underscore the urgent need for strengthened surveillance and public health interventions to combat carbapenemase-mediated resistance in the region. Funding: None. |
| format | Article |
| id | doaj-art-f11a27f3dc4740a38425ff2a3be9621f |
| institution | DOAJ |
| issn | 2667-193X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Americas |
| spelling | doaj-art-f11a27f3dc4740a38425ff2a3be9621f2025-08-20T03:13:11ZengElsevierThe Lancet Regional Health. Americas2667-193X2025-09-014910118510.1016/j.lana.2025.101185Carbapenemases producing gram-negative bacteria surveillance in Latin America and the caribbean: a retrospective observational study from 2015 to 2020Research in contextMarcelo Pillonetto0Priscila Lamb Wink1Roberto G. Melano2María Antonieta Jiménez-Pearson3Nancy Lorena Melgarejo Touchet4Sandra Yamile Saavedra Rojas5Debora N.O. Kulek6Andre Luiz Abreu7Renata Tigulini Peral8Rogerio Miorando9Hatim Sati10Genara Romero Thomas11Marcelo Galas12Pilar Ramon Pardo13Carlos R.V. Kiffer14Ana Paula D'Alincourt Carvalho Assef15Marinonio Ana Sílvia ScavaciniCosta-Nobre Daniela TestoniGonçalves Geiziane AparecidaJesus Ronaldo deRezende Thais F. THormazabal Juan CarlosAraya PamelaOvalle María VictoriaDuarte CarolinaÁlvarez Tábata ElizondoHernández Priscilla BaltodanoIllnait María TeresaQuiñones DianelysSalazar Carolina SatanRomán KarlaGrande MiguelBoza Maria LunaHerrera AndrésHerrera Carmen Julia MazariegosAcuña Julissa Maria AvilaLira Lissette Carolina SandovalBusignani SofíaBrítez MarielGavilan RonnieFlores-Leon DianaLopez MarianaCaiata LeticiaPalmar Kerlin Vanessa MarcanoNoguera Carmen Isaura UgarteTorrico ElizabethCopa HelenLaboratorio Central de Saúde Pública do Paraná, São José dos Pinhais, PR, Brazil; Pontificia Universidade Católica do Paraná, Curitiba, PR, Brazil; Corresponding author. Laboratorio Central de Saúde Pública do Paraná, São José dos Pinhais, PR, Brazil.Pan American Health Organization, Antimicrobial Resistance Team, AMR Special Program, Washington, DC, USAPan American Health Organization, Antimicrobial Resistance Team, AMR Special Program, Washington, DC, USACentro Nacional de Referencia de Bacteriología, Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud (Inciensa), Cartago, Costa RicaSección Antimicrobianos, Dpto. Bacteriología y Micología, Laboratorio Central de Salud Pública, Ministerio de Salud Pública y Bienestar Social, ParaguayGrupo Microbiología, Dirección Redes en Salud Pública, Subdirección Laboratorio Nacional de Referencia, Instituto Nacional de Salud Colombia, Bogotá, ColombiaCoordenação Geral de Laboratórios de Saúde Pública, Secretaria de Vigilância em Saúde e Ambiente, Ministério da Saúde, Brasília, DF, BrazilCoordenação Geral de Laboratórios de Saúde Pública, Secretaria de Vigilância em Saúde e Ambiente, Ministério da Saúde, Brasília, DF, BrazilCoordenação Geral de Laboratórios de Saúde Pública, Secretaria de Vigilância em Saúde e Ambiente, Ministério da Saúde, Brasília, DF, BrazilDepartamento de Engenharia de Produçao, Universidade Federal de Santa Catarina, Florianópolis, SC, BrazilWorld Health Organization, AMR Division, Geneva, SwitzerlandPan American Health Organization, Antimicrobial Resistance Team, AMR Special Program, Washington, DC, USAPan American Health Organization, Antimicrobial Resistance Team, AMR Special Program, Washington, DC, USAPan American Health Organization, Antimicrobial Resistance Team, AMR Special Program, Washington, DC, USAGrupo de Análises em Infecções e Antimicrobianos (GAIA), Laboratório Especial de Microbiologia Clínica (LEMC), Disciplina de Infectologia, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, BrazilLaboratório de Bacteriologia Aplicada a Saúde Única e Resistência Antimicrobiana (LabSUR), Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, RJ, BrazilSummary: Background: The rise of multidrug-resistant (MDR) bacteria represents a public health threat, with carbapenem resistance exacerbating this challenge. This study investigates carbapenemase-producing bacteria (CPB) across the Latin America and the Caribbean (LAC) region. Methods: A retrospective observational study was conducted across 12 LAC countries from 2015 to 2020. A total of 58,909 isolates were analyzed utilizing polymerase chain reaction (PCR) to detect key carbapenemases in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii complex (ABC). Findings: 47,804/58,909 (81.14%) carbapenemases were identified, with Brazil accounting for 73% of these. The majority were reported in carbapenem-resistant Enterobacterales–CRE (65.33%; 31,230/47,804), followed by carbapenem-resistant ABC-CRAB (22.05%; 10,542/47,804), and carbapenem-resistant P. aeruginosa–CRPA (6050/47,804; 12.66%). Among CRE, blaKPC was the most detected gene (78.67%; 24,569/31,230), with Klebsiella pneumoniae being the most commonly associated species (75.9%). A relevant upward trend in blaNDM was observed. CRPA exhibited diverse profiles, with blaVIM (47.64%) being the most common. In CRAB, blaOXA-23 was found in 88.80% (9361/10,542) of isolates. Carbapenemase co-production was detected in 2.60% (1190/47,804) of isolates, with CRPA blaIMP + blaVIM being the most frequent. Interpretation: This study highlights a high prevalence of CPB in LAC, with a stable trend in blaKPC but a rising trend in blaNDM. These findings underscore the urgent need for strengthened surveillance and public health interventions to combat carbapenemase-mediated resistance in the region. Funding: None.http://www.sciencedirect.com/science/article/pii/S2667193X25001954Multidrug-resistant bacteriaCarbapenemasesLatin AmericaAntimicrobial resistancePublic health challenge |
| spellingShingle | Marcelo Pillonetto Priscila Lamb Wink Roberto G. Melano María Antonieta Jiménez-Pearson Nancy Lorena Melgarejo Touchet Sandra Yamile Saavedra Rojas Debora N.O. Kulek Andre Luiz Abreu Renata Tigulini Peral Rogerio Miorando Hatim Sati Genara Romero Thomas Marcelo Galas Pilar Ramon Pardo Carlos R.V. Kiffer Ana Paula D'Alincourt Carvalho Assef Marinonio Ana Sílvia Scavacini Costa-Nobre Daniela Testoni Gonçalves Geiziane Aparecida Jesus Ronaldo de Rezende Thais F. T Hormazabal Juan Carlos Araya Pamela Ovalle María Victoria Duarte Carolina Álvarez Tábata Elizondo Hernández Priscilla Baltodano Illnait María Teresa Quiñones Dianelys Salazar Carolina Satan Román Karla Grande Miguel Boza Maria Luna Herrera Andrés Herrera Carmen Julia Mazariegos Acuña Julissa Maria Avila Lira Lissette Carolina Sandoval Busignani Sofía Brítez Mariel Gavilan Ronnie Flores-Leon Diana Lopez Mariana Caiata Leticia Palmar Kerlin Vanessa Marcano Noguera Carmen Isaura Ugarte Torrico Elizabeth Copa Helen Carbapenemases producing gram-negative bacteria surveillance in Latin America and the caribbean: a retrospective observational study from 2015 to 2020Research in context The Lancet Regional Health. Americas Multidrug-resistant bacteria Carbapenemases Latin America Antimicrobial resistance Public health challenge |
| title | Carbapenemases producing gram-negative bacteria surveillance in Latin America and the caribbean: a retrospective observational study from 2015 to 2020Research in context |
| title_full | Carbapenemases producing gram-negative bacteria surveillance in Latin America and the caribbean: a retrospective observational study from 2015 to 2020Research in context |
| title_fullStr | Carbapenemases producing gram-negative bacteria surveillance in Latin America and the caribbean: a retrospective observational study from 2015 to 2020Research in context |
| title_full_unstemmed | Carbapenemases producing gram-negative bacteria surveillance in Latin America and the caribbean: a retrospective observational study from 2015 to 2020Research in context |
| title_short | Carbapenemases producing gram-negative bacteria surveillance in Latin America and the caribbean: a retrospective observational study from 2015 to 2020Research in context |
| title_sort | carbapenemases producing gram negative bacteria surveillance in latin america and the caribbean a retrospective observational study from 2015 to 2020research in context |
| topic | Multidrug-resistant bacteria Carbapenemases Latin America Antimicrobial resistance Public health challenge |
| url | http://www.sciencedirect.com/science/article/pii/S2667193X25001954 |
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