Integrating immune library probing with structure-based computational design to develop potent neutralizing nanobodies against emerging SARS-CoV-2 variants

Integrating immune library probing with structure-based computational design to develop potent neutralizing nanobodies against emerging SARS-CoV-2 variants

To generate antibodies (Abs) against SARS-CoV-2 emerging variants, we integrated multiple tools and engineered molecules with excellent neutralizing breadth and potency. Initially, the screening of an immune library identified a nanobody (Nb), termed Nb4, specific to the receptor-binding domain (RBD...

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Bibliographic Details
Main Authors: Lidia Cerdán, Katixa Silva, Daniel Rodríguez-Martín, Patricia Pérez, María A. Noriega, Ana Esteban Martín, Alfonso Gutiérrez-Adán, Yago Margolles, Juan A. Corbera, Miguel A. Martín-Acebes, Juan García-Arriaza, Juan Fernández-Recio, Luis A. Fernández, José M. Casasnovas
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Antibody evolution
bioinformatics
crystallography
nanobodies
protein interactions
SARS-CoV-2
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2499595
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