Helicobacter pylori infection recurrence in developed versus developing countries – a systematic review and meta-analysis
Objective: Half of the world’s population is infected with Helicobacter pylori (H. pylori), which can cause gastric diseases and must be eradicated. The reinfection rate, the colonization rate with a new strain usually after more than 12 months of successful eradication, is considered higher in deve...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Verduci Editore
2024-11-01
|
| Series: | Microbiota in Health and Disease |
| Subjects: | |
| Online Access: | https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/11/e1158-1.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841560930641510400 |
|---|---|
| author | M. Schechter Y. Niv |
| author_facet | M. Schechter Y. Niv |
| author_sort | M. Schechter |
| collection | DOAJ |
| description | Objective: Half of the world’s population is infected with Helicobacter pylori (H. pylori), which can cause gastric diseases and must be eradicated. The reinfection rate, the colonization rate with a new strain usually after more than 12 months of successful eradication, is considered higher in developing countries than developed countries due to lower investment in sanitation and hygiene or a higher population density. The study aimed to analyze and understand H. pylori recurrence rates in developed and developing countries and compare the results from 2013 to 2023 to those between 1992 and 2006.
Patients and Methods: PubMed, Google Scholar, Embase, and Scopus databases were searched up to December 31, 2023, using the keywords “Helicobacter pylori” or “H. pylori” and “recurrence” or “recrudescence” or “reinfection”. Clinical studies examining the recurrence rate of H. pylori following successful eradication therapy were included, specifically those that provide clear, quantifiable results for comparison. Meta-analysis was performed with comprehensive meta-analysis software, version 4 (Biostat Inc., Englewood, NJ, USA).
Results: 5,808 articles were screened and 20 articles (35 data sets with 16,785 participants) from 11 countries were finally enrolled for analysis. The annual recurrence rate ranged from 0% to 18.80%. The annual reinfection rates in developing and developed countries were 0.040, 95% CI 0.030 to 0.052, and 0.030, 95% CI 0.018 to 0.051, respectively.
Conclusions: No significant change in the recurrence rate between developed and developing countries was demonstrated, possibly due to better hygiene status in developing countries as achieved in the last decade. |
| format | Article |
| id | doaj-art-f0eb4d9b10f8440d96da9edde43763ac |
| institution | Kabale University |
| issn | 2704-8845 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Verduci Editore |
| record_format | Article |
| series | Microbiota in Health and Disease |
| spelling | doaj-art-f0eb4d9b10f8440d96da9edde43763ac2025-01-03T10:30:12ZengVerduci EditoreMicrobiota in Health and Disease2704-88452024-11-01610.26355/mhd_202411_11581158Helicobacter pylori infection recurrence in developed versus developing countries – a systematic review and meta-analysisM. Schechter0Y. Niv1Adelson Faculty of Medicine, Ariel University, Ariel, IsraelAdelson Faculty of Medicine, Ariel University, Ariel, IsraelObjective: Half of the world’s population is infected with Helicobacter pylori (H. pylori), which can cause gastric diseases and must be eradicated. The reinfection rate, the colonization rate with a new strain usually after more than 12 months of successful eradication, is considered higher in developing countries than developed countries due to lower investment in sanitation and hygiene or a higher population density. The study aimed to analyze and understand H. pylori recurrence rates in developed and developing countries and compare the results from 2013 to 2023 to those between 1992 and 2006. Patients and Methods: PubMed, Google Scholar, Embase, and Scopus databases were searched up to December 31, 2023, using the keywords “Helicobacter pylori” or “H. pylori” and “recurrence” or “recrudescence” or “reinfection”. Clinical studies examining the recurrence rate of H. pylori following successful eradication therapy were included, specifically those that provide clear, quantifiable results for comparison. Meta-analysis was performed with comprehensive meta-analysis software, version 4 (Biostat Inc., Englewood, NJ, USA). Results: 5,808 articles were screened and 20 articles (35 data sets with 16,785 participants) from 11 countries were finally enrolled for analysis. The annual recurrence rate ranged from 0% to 18.80%. The annual reinfection rates in developing and developed countries were 0.040, 95% CI 0.030 to 0.052, and 0.030, 95% CI 0.018 to 0.051, respectively. Conclusions: No significant change in the recurrence rate between developed and developing countries was demonstrated, possibly due to better hygiene status in developing countries as achieved in the last decade.https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/11/e1158-1.pdfh. pylorirecurrencerecrudescencereinfectionmeta-analysis. |
| spellingShingle | M. Schechter Y. Niv Helicobacter pylori infection recurrence in developed versus developing countries – a systematic review and meta-analysis Microbiota in Health and Disease h. pylori recurrence recrudescence reinfection meta-analysis. |
| title | Helicobacter pylori infection recurrence in developed versus developing countries – a systematic review and meta-analysis |
| title_full | Helicobacter pylori infection recurrence in developed versus developing countries – a systematic review and meta-analysis |
| title_fullStr | Helicobacter pylori infection recurrence in developed versus developing countries – a systematic review and meta-analysis |
| title_full_unstemmed | Helicobacter pylori infection recurrence in developed versus developing countries – a systematic review and meta-analysis |
| title_short | Helicobacter pylori infection recurrence in developed versus developing countries – a systematic review and meta-analysis |
| title_sort | helicobacter pylori infection recurrence in developed versus developing countries a systematic review and meta analysis |
| topic | h. pylori recurrence recrudescence reinfection meta-analysis. |
| url | https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/11/e1158-1.pdf |
| work_keys_str_mv | AT mschechter helicobacterpyloriinfectionrecurrenceindevelopedversusdevelopingcountriesasystematicreviewandmetaanalysis AT yniv helicobacterpyloriinfectionrecurrenceindevelopedversusdevelopingcountriesasystematicreviewandmetaanalysis |