Commentary on “A Microfluidic Platform to Design Crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for Enhanced MRI”
Strategies to enhance the relaxometric properties of gadolinium (Gd)-based contrast agents (CAs) for magnetic resonance imaging (MRI), without the chemical modification of chelates, have recently had a strong impact on the diagnostic field. We have taken advantage of the interaction between Gadolini...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-08-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012117706237 |
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| author | Maria Russo PhD Paolo Bevilacqua PhD Paolo Antonio Netti PhD Enza Torino PhD |
| author_facet | Maria Russo PhD Paolo Bevilacqua PhD Paolo Antonio Netti PhD Enza Torino PhD |
| author_sort | Maria Russo PhD |
| collection | DOAJ |
| description | Strategies to enhance the relaxometric properties of gadolinium (Gd)-based contrast agents (CAs) for magnetic resonance imaging (MRI), without the chemical modification of chelates, have recently had a strong impact on the diagnostic field. We have taken advantage of the interaction between Gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) and the hydrogel structure of hyaluronic acid to design cross-linked hyaluronic acid nanoparticles down to 35 nm for use in MRI applications. The proposed bioformulations enable the control of the relaxometric properties of CAs, thus boosting the relaxation rate of T1. Our results led us to identify this approach as an adjustable scenario to design intravascularly injectable hydrogel nanoparticles entrapping Gd-DTPA. This approach overcomes the general drawbacks of clinically approved CAs having poor relaxivity and toxic effects. |
| format | Article |
| id | doaj-art-f0e16a8a42504e968c424207ad92bb03 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2017-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-f0e16a8a42504e968c424207ad92bb032025-01-02T21:31:17ZengSAGE PublishingMolecular Imaging1536-01212017-08-011610.1177/153601211770623710.1177_1536012117706237Commentary on “A Microfluidic Platform to Design Crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for Enhanced MRI”Maria Russo PhD0Paolo Bevilacqua PhD1Paolo Antonio Netti PhD2Enza Torino PhD3 Department of Chemical Engineering, Materials and Industrial Production, University of Naples Federico II, Naples, Italy IRCCS SDN, Naples, Italy Interdisciplinary Research Center on Biomaterials, University of Naples Federico II, Naples, Italy Interdisciplinary Research Center on Biomaterials, University of Naples Federico II, Naples, ItalyStrategies to enhance the relaxometric properties of gadolinium (Gd)-based contrast agents (CAs) for magnetic resonance imaging (MRI), without the chemical modification of chelates, have recently had a strong impact on the diagnostic field. We have taken advantage of the interaction between Gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) and the hydrogel structure of hyaluronic acid to design cross-linked hyaluronic acid nanoparticles down to 35 nm for use in MRI applications. The proposed bioformulations enable the control of the relaxometric properties of CAs, thus boosting the relaxation rate of T1. Our results led us to identify this approach as an adjustable scenario to design intravascularly injectable hydrogel nanoparticles entrapping Gd-DTPA. This approach overcomes the general drawbacks of clinically approved CAs having poor relaxivity and toxic effects.https://doi.org/10.1177/1536012117706237 |
| spellingShingle | Maria Russo PhD Paolo Bevilacqua PhD Paolo Antonio Netti PhD Enza Torino PhD Commentary on “A Microfluidic Platform to Design Crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for Enhanced MRI” Molecular Imaging |
| title | Commentary on “A Microfluidic Platform to Design Crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for Enhanced MRI” |
| title_full | Commentary on “A Microfluidic Platform to Design Crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for Enhanced MRI” |
| title_fullStr | Commentary on “A Microfluidic Platform to Design Crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for Enhanced MRI” |
| title_full_unstemmed | Commentary on “A Microfluidic Platform to Design Crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for Enhanced MRI” |
| title_short | Commentary on “A Microfluidic Platform to Design Crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for Enhanced MRI” |
| title_sort | commentary on a microfluidic platform to design crosslinked hyaluronic acid nanoparticles chanps for enhanced mri |
| url | https://doi.org/10.1177/1536012117706237 |
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