Proteolytic Processing of CD44 and Its Implications in Cancer
CD44 is a transmembrane glycoprotein expressed in several healthy and tumor tissues. Modifications in its structure contribute differently to the activity of this molecule. One modification that has provoked interest is the consecutive cleavage of the CD44 extracellular ectodomain by enzymes that be...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/6667735 |
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| _version_ | 1841524583281197056 |
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| author | Priscila Anhel Medrano-González Osmar Rivera-Ramírez Luis Felipe Montaño Erika P. Rendón-Huerta |
| author_facet | Priscila Anhel Medrano-González Osmar Rivera-Ramírez Luis Felipe Montaño Erika P. Rendón-Huerta |
| author_sort | Priscila Anhel Medrano-González |
| collection | DOAJ |
| description | CD44 is a transmembrane glycoprotein expressed in several healthy and tumor tissues. Modifications in its structure contribute differently to the activity of this molecule. One modification that has provoked interest is the consecutive cleavage of the CD44 extracellular ectodomain by enzymes that belong mainly to the family of metalloproteases. This process releases biologically active substrates, via alternative splice forms of CD44, that generate CD44v3 or v6 isoforms which participate in the transcriptional regulation of genes and proteins associated to signaling pathways involved in the development of cancer. These include the protooncogene tyrosine-protein kinase Src (c-Src)/signal transducer and activator of transcription 3 (STAT3), the epithelial growth factor receptor, the estrogen receptor, Wnt/βcatenin, or Hippo signaling pathways all of which are associated to cell proliferation, differentiation, or cancer progression. Whereas CD44 still remains as a very useful prognostic cell marker in different pathologies, the main topic is that the generation of CD44 intracellular fragments assists the regulation of transcriptional proteins involved in the cell cycle, cell metabolism, and most importantly, the regulation of some stem cell-associated markers. |
| format | Article |
| id | doaj-art-f0cfd6f59f7142e999545a2e15bdfa1b |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f0cfd6f59f7142e999545a2e15bdfa1b2025-02-03T05:52:57ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/66677356667735Proteolytic Processing of CD44 and Its Implications in CancerPriscila Anhel Medrano-González0Osmar Rivera-Ramírez1Luis Felipe Montaño2Erika P. Rendón-Huerta3Lab. Inmunobiología, Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, Mexico, MexicoLab. Inmunobiología, Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, Mexico, MexicoLab. Inmunobiología, Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, Mexico, MexicoLab. Inmunobiología, Depto. Biología Celular y Tisular, Facultad de Medicina, UNAM, Mexico, MexicoCD44 is a transmembrane glycoprotein expressed in several healthy and tumor tissues. Modifications in its structure contribute differently to the activity of this molecule. One modification that has provoked interest is the consecutive cleavage of the CD44 extracellular ectodomain by enzymes that belong mainly to the family of metalloproteases. This process releases biologically active substrates, via alternative splice forms of CD44, that generate CD44v3 or v6 isoforms which participate in the transcriptional regulation of genes and proteins associated to signaling pathways involved in the development of cancer. These include the protooncogene tyrosine-protein kinase Src (c-Src)/signal transducer and activator of transcription 3 (STAT3), the epithelial growth factor receptor, the estrogen receptor, Wnt/βcatenin, or Hippo signaling pathways all of which are associated to cell proliferation, differentiation, or cancer progression. Whereas CD44 still remains as a very useful prognostic cell marker in different pathologies, the main topic is that the generation of CD44 intracellular fragments assists the regulation of transcriptional proteins involved in the cell cycle, cell metabolism, and most importantly, the regulation of some stem cell-associated markers.http://dx.doi.org/10.1155/2021/6667735 |
| spellingShingle | Priscila Anhel Medrano-González Osmar Rivera-Ramírez Luis Felipe Montaño Erika P. Rendón-Huerta Proteolytic Processing of CD44 and Its Implications in Cancer Stem Cells International |
| title | Proteolytic Processing of CD44 and Its Implications in Cancer |
| title_full | Proteolytic Processing of CD44 and Its Implications in Cancer |
| title_fullStr | Proteolytic Processing of CD44 and Its Implications in Cancer |
| title_full_unstemmed | Proteolytic Processing of CD44 and Its Implications in Cancer |
| title_short | Proteolytic Processing of CD44 and Its Implications in Cancer |
| title_sort | proteolytic processing of cd44 and its implications in cancer |
| url | http://dx.doi.org/10.1155/2021/6667735 |
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