Early prevention of carrageenan-induced peripheral/spinal inflammation suppresses microglial hyperreactivity in the trigeminal spinal subnucleus caudalis and alleviates chronic facial nociception

Early prevention of carrageenan-induced peripheral/spinal inflammation suppresses microglial hyperreactivity in the trigeminal spinal subnucleus caudalis and alleviates chronic facial nociception

In this study, we investigated the mechanisms underlying carrageenan-induced chronic pain and the therapeutic effect of the anti-inflammatory drug meloxicam. Rats were injected with 3 % carrageenan into the masseter muscle. These rats exhibited acute and chronic hypersensitivity to mechanical stimul...

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Bibliographic Details
Main Authors: Toru Yamamoto, Mitsuhiro Yoshida, Yuhei Koyama, Yatendra Mulpuri, Eiji Imado, Kana Oue, Mitsuru Doi, Yoshitaka Shimizu, Naotaka Kishimoto, Hiroshi Hanamoto, Kenji Seo
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
Carrageenan
Inflammation
Orofacial chronic pain
Microglia
Trigeminal spinal subnucleus caudalis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024176335
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