Tandospirone prevents anesthetic-induced respiratory depression through 5-HT1A receptor activation in rats

Tandospirone prevents anesthetic-induced respiratory depression through 5-HT1A receptor activation in rats

Abstract Respiratory depression is a side effect of anesthetics. Treatment with specific antagonists or respiratory stimulants can reverse respiratory depression caused by anesthetics; however, they also interfere with the sedative effects of anesthetics. Previous studies have suggested that tandosp...

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Bibliographic Details
Main Authors: Meng-ran Song, Ming-zhi Huang, Wei-jie Tao, Zheng Yong, Rui-bin Su
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
5-HT1A
Tandospirone
Respiratory depression
Fentanyl
Midazolam
Dexmedetomidine
Online Access:https://doi.org/10.1038/s41598-024-84440-x
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