S6P mutation in Delta and Omicron variant spike protein significantly enhances the efficacy of mRNA COVID-19 vaccines

S6P mutation in Delta and Omicron variant spike protein significantly enhances the efficacy of mRNA COVID-19 vaccines

BackgroundThe unrelenting emergence of SARS-CoV-2 variants has significantly challenged the efficacy of existing COVID-19 vaccines. Enhancing the stability and immunogenicity of the spike protein is critical for improving vaccine performance and addressing variant-driven immune evasion.MethodsWe dev...

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Bibliographic Details
Main Authors: Yong-Sik Bong, David Brown, Ezra Chung, Neeti Ananthaswamy, Renxiang Chen, Evan Lewoczko, William Sabbers, Athéna C. Patterson-Orazem, Zachary Dorsey, Yiqing Zou, Xue Yu, Jiening Liang, Jiaxi He, Steven Long, Dong Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
lipid nanoparticles (LNPs)
mRNA vaccines
SARS-CoV-2 spike protein
immunogenicity
neutralizing antibodies
Delta and Omicron variant
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1495561/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1495561/full

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