Inactivation of the porB gene reduces the virulence of Neisseria meningitidis in transgenic mice

Inactivation of the porB gene reduces the virulence of Neisseria meningitidis in transgenic mice

Abstract Background Neisseria meningitidis is a human pathogen, carried asymptomatically in the nasopharynx, that can also cause invasive meningococcal disease. Understanding the carriage/invasiveness balance is crucial, and bacterial genetic factors may impact this balance. A previous genome-wide a...

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Bibliographic Details
Main Authors: Cecilia Klanger, Ala-Eddine Deghmane, Lorraine Eriksson, Olof Säll, Sara Thulin Hedberg, Paula Mölling, Muhamed-Kheir Taha
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Microbiology
Subjects:
Neisseria meningitidis
Carriage
Invasive meningococcal disease
Transgenic mice
PorB
Inflammatory cytokines
Online Access:https://doi.org/10.1186/s12866-025-04246-3
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