Pretransplant hypoalbuminemia may be associated with poor survival in patients that underwent autologous hematopoietic stem cell transplantation (autoHSCT)
Objectives and aim: Serum albumin level is mainly a marker of nutritional status in both healthy subjects and patients with malignancies. Our objective was to investigate the association of pre-transplant serum albumin levels with prognosis in autologous HSCT recipients. Materials and methods: W...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1729 |
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| author | Serdar Sivgin Suleyman Baldane Leylagul Kaynar Fatih Kurnaz Muzaffer Keklik Cigdem Pala Gokmen Zararsiz Bulent Eser Mustafa Cetin Ali Unal |
| author_facet | Serdar Sivgin Suleyman Baldane Leylagul Kaynar Fatih Kurnaz Muzaffer Keklik Cigdem Pala Gokmen Zararsiz Bulent Eser Mustafa Cetin Ali Unal |
| author_sort | Serdar Sivgin |
| collection | DOAJ |
| description | Objectives and aim: Serum albumin level is mainly a marker of nutritional status in both healthy subjects and patients with malignancies. Our objective was to investigate the association of pre-transplant serum albumin levels with prognosis in autologous HSCT recipients.
Materials and methods: We retrospectively analysed 106 patients’ data who had undergone autologous HSCT diagnosed with multiple myeloma, Hodgkin Lymphoma and Non-Hodgkin Lymphoma. Serum albumin, phosphorus, D-dimer and uric acid, CD34+ cell count, BMI, presence of neutropenic fever of 106 patients were evaluated. The patients’ data were obtained from the file records.
Results: 33 (31.1%) of the patients were female, and 73 (68.9%) were male. The diagnosis of the patients were; Hodgkin Lyphoma (33 patients, 31.1%), non-Hodgkin lymphoma (34 patients, 32.1%), and multiple myeloma (39 patients, 36.8%). The median age was found 42 years (min-max: 17-67). Univariate and multivariate analysis showed that low albumin levels (<3.2g /dL) were associated with decreased overall survival (OS) and disease-free survival (DFS) compared to those with normal albumin levels (p=0.016 and p=0.001 respectively). A higher risk of death was observed in low-albumin group (HR=2.69, CI:1.17-6.24, p=0.016 for OS and HR=2.69,CI:1.17-6.24 p=0.001 for DFS). Cox regression analysis showed that; low albumin levels were associated with increased risk of relapse but this was not statistically significant (HR:0.97 with %95 CI:0.28-3.32, p=0.96). Serum uric acid, D-dimer, phosphorus levels, CD34+ cell count, BMI, presence of neutropenic fever, age and gender were not associated with poor OS and DFS (p>0.05).
Conclusion: Pre-transplant serum albumin levels may be associated with poor outcomes in patients who had undergone autologous hematopoietic stem cell transplantation regardless with primary diagnosis. |
| format | Article |
| id | doaj-art-f0a4b78b67b448d1a3c0d0cef1e5c185 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-f0a4b78b67b448d1a3c0d0cef1e5c1852025-01-02T10:51:24ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011Pretransplant hypoalbuminemia may be associated with poor survival in patients that underwent autologous hematopoietic stem cell transplantation (autoHSCT)Serdar Sivgin0Suleyman Baldane1Leylagul Kaynar2Fatih Kurnaz3Muzaffer Keklik4Cigdem Pala5Gokmen Zararsiz6Bulent Eser7Mustafa Cetin8Ali Unal9Dedeman Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri.Department of Internal Medicine, Faculty of Medicine, Erciyes University, Kayseri.Dedeman Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri.Dedeman Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri.Dedeman Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri.Dedeman Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri.Department of Medical Statistics; Faculty of Medicine, Erciyes University, KayseriDedeman Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri.Dedeman Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri.Dedeman Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri.Objectives and aim: Serum albumin level is mainly a marker of nutritional status in both healthy subjects and patients with malignancies. Our objective was to investigate the association of pre-transplant serum albumin levels with prognosis in autologous HSCT recipients. Materials and methods: We retrospectively analysed 106 patients’ data who had undergone autologous HSCT diagnosed with multiple myeloma, Hodgkin Lymphoma and Non-Hodgkin Lymphoma. Serum albumin, phosphorus, D-dimer and uric acid, CD34+ cell count, BMI, presence of neutropenic fever of 106 patients were evaluated. The patients’ data were obtained from the file records. Results: 33 (31.1%) of the patients were female, and 73 (68.9%) were male. The diagnosis of the patients were; Hodgkin Lyphoma (33 patients, 31.1%), non-Hodgkin lymphoma (34 patients, 32.1%), and multiple myeloma (39 patients, 36.8%). The median age was found 42 years (min-max: 17-67). Univariate and multivariate analysis showed that low albumin levels (<3.2g /dL) were associated with decreased overall survival (OS) and disease-free survival (DFS) compared to those with normal albumin levels (p=0.016 and p=0.001 respectively). A higher risk of death was observed in low-albumin group (HR=2.69, CI:1.17-6.24, p=0.016 for OS and HR=2.69,CI:1.17-6.24 p=0.001 for DFS). Cox regression analysis showed that; low albumin levels were associated with increased risk of relapse but this was not statistically significant (HR:0.97 with %95 CI:0.28-3.32, p=0.96). Serum uric acid, D-dimer, phosphorus levels, CD34+ cell count, BMI, presence of neutropenic fever, age and gender were not associated with poor OS and DFS (p>0.05). Conclusion: Pre-transplant serum albumin levels may be associated with poor outcomes in patients who had undergone autologous hematopoietic stem cell transplantation regardless with primary diagnosis.https://mjhid.org/index.php/mjhid/article/view/1729albuminautoHSCTsurvivallymphomamultiple myeloma |
| spellingShingle | Serdar Sivgin Suleyman Baldane Leylagul Kaynar Fatih Kurnaz Muzaffer Keklik Cigdem Pala Gokmen Zararsiz Bulent Eser Mustafa Cetin Ali Unal Pretransplant hypoalbuminemia may be associated with poor survival in patients that underwent autologous hematopoietic stem cell transplantation (autoHSCT) Mediterranean Journal of Hematology and Infectious Diseases albumin autoHSCT survival lymphoma multiple myeloma |
| title | Pretransplant hypoalbuminemia may be associated with poor survival in patients that underwent autologous hematopoietic stem cell transplantation (autoHSCT) |
| title_full | Pretransplant hypoalbuminemia may be associated with poor survival in patients that underwent autologous hematopoietic stem cell transplantation (autoHSCT) |
| title_fullStr | Pretransplant hypoalbuminemia may be associated with poor survival in patients that underwent autologous hematopoietic stem cell transplantation (autoHSCT) |
| title_full_unstemmed | Pretransplant hypoalbuminemia may be associated with poor survival in patients that underwent autologous hematopoietic stem cell transplantation (autoHSCT) |
| title_short | Pretransplant hypoalbuminemia may be associated with poor survival in patients that underwent autologous hematopoietic stem cell transplantation (autoHSCT) |
| title_sort | pretransplant hypoalbuminemia may be associated with poor survival in patients that underwent autologous hematopoietic stem cell transplantation autohsct |
| topic | albumin autoHSCT survival lymphoma multiple myeloma |
| url | https://mjhid.org/index.php/mjhid/article/view/1729 |
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