The comparison of the prognostic value of different inflammation-related indicators in patients with oral squamous cell carcinoma
BackgroundThis study aimed to determine the prognostic significance of inflammation markers for patients with oral squamous cell carcinoma (OSCC) and sought to analyze the reasons behind it and its value for clinical guidance.MethodsThis study enrolled 624 patients with OSCC who were surgically trea...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2025.1652603/full |
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| author | Aoming Cheng Kaixiong Wei Qiaoshi Xu Chong Wang Bo Li Huan Liu Lirui Zhang Hanchen Zhou Yu Huang Yiming Zhang Xue Zhang Hao Wang Chang Liu Teng Ma Jingrui Li Zhengxue Han Zhien Feng |
| author_facet | Aoming Cheng Kaixiong Wei Qiaoshi Xu Chong Wang Bo Li Huan Liu Lirui Zhang Hanchen Zhou Yu Huang Yiming Zhang Xue Zhang Hao Wang Chang Liu Teng Ma Jingrui Li Zhengxue Han Zhien Feng |
| author_sort | Aoming Cheng |
| collection | DOAJ |
| description | BackgroundThis study aimed to determine the prognostic significance of inflammation markers for patients with oral squamous cell carcinoma (OSCC) and sought to analyze the reasons behind it and its value for clinical guidance.MethodsThis study enrolled 624 patients with OSCC who were surgically treated in our hospital. Clinical baseline data and peripheral blood routine/biochemical parameters were collected within 1 week before surgery. The Kaplan-Meier analysis and Cox multifactor regression analysis were performed for statistical analysis. Time-dependent receiver operating characteristic curves (ROC) were used to explore the timeliness of inflammation-related indicators.ResultsThe Kaplan-Meier analysis revealed that patients with a high-inflammatory trend had significantly shorter overall survival (OS) and disease-free survival (DFS) compared to the patients with a low-inflammatory trend (P < 0.05). Cox multivariate regression analysis demonstrated that advanced lung cancer inflammation index (ALI) and prognostic nutritional index (PNI) were correlated with OS of OSCC patients. Additionally, Subgroup analysis found that ALI and PNI served as independent prognostic factors for OS in male patients. In age-stratified analyses, ALI and PNI also emerged as independent predictors of OS for patients <60 years time-dependent ROC, which ALI demonstrated the best predictive performance for short-term postoperative prognosis (area under the curve (AUC) = 0.74).ConclusionALI and PNI are valuable prognostic indicators in the short term after surgery for young male patients under 60 years old with OSCC. |
| format | Article |
| id | doaj-art-f09fc5a6a1ab481fa1e92f37aa3d9ee7 |
| institution | Kabale University |
| issn | 1664-8021 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj-art-f09fc5a6a1ab481fa1e92f37aa3d9ee72025-08-20T03:46:50ZengFrontiers Media S.A.Frontiers in Genetics1664-80212025-08-011610.3389/fgene.2025.16526031652603The comparison of the prognostic value of different inflammation-related indicators in patients with oral squamous cell carcinomaAoming Cheng0Kaixiong Wei1Qiaoshi Xu2Chong Wang3Bo Li4Huan Liu5Lirui Zhang6Hanchen Zhou7Yu Huang8Yiming Zhang9Xue Zhang10Hao Wang11Chang Liu12Teng Ma13Jingrui Li14Zhengxue Han15Zhien Feng16Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Stomatology, Beijing Huairou Hospital, Beijing, ChinaDepartment of Clinical Laboratory, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, ChinaBackgroundThis study aimed to determine the prognostic significance of inflammation markers for patients with oral squamous cell carcinoma (OSCC) and sought to analyze the reasons behind it and its value for clinical guidance.MethodsThis study enrolled 624 patients with OSCC who were surgically treated in our hospital. Clinical baseline data and peripheral blood routine/biochemical parameters were collected within 1 week before surgery. The Kaplan-Meier analysis and Cox multifactor regression analysis were performed for statistical analysis. Time-dependent receiver operating characteristic curves (ROC) were used to explore the timeliness of inflammation-related indicators.ResultsThe Kaplan-Meier analysis revealed that patients with a high-inflammatory trend had significantly shorter overall survival (OS) and disease-free survival (DFS) compared to the patients with a low-inflammatory trend (P < 0.05). Cox multivariate regression analysis demonstrated that advanced lung cancer inflammation index (ALI) and prognostic nutritional index (PNI) were correlated with OS of OSCC patients. Additionally, Subgroup analysis found that ALI and PNI served as independent prognostic factors for OS in male patients. In age-stratified analyses, ALI and PNI also emerged as independent predictors of OS for patients <60 years time-dependent ROC, which ALI demonstrated the best predictive performance for short-term postoperative prognosis (area under the curve (AUC) = 0.74).ConclusionALI and PNI are valuable prognostic indicators in the short term after surgery for young male patients under 60 years old with OSCC.https://www.frontiersin.org/articles/10.3389/fgene.2025.1652603/fullOSCCinflammation-related indicatorsprognostic nutritional index (PNI)advanced lung cancer inflammation index (ALI)prognosis prediction |
| spellingShingle | Aoming Cheng Kaixiong Wei Qiaoshi Xu Chong Wang Bo Li Huan Liu Lirui Zhang Hanchen Zhou Yu Huang Yiming Zhang Xue Zhang Hao Wang Chang Liu Teng Ma Jingrui Li Zhengxue Han Zhien Feng The comparison of the prognostic value of different inflammation-related indicators in patients with oral squamous cell carcinoma Frontiers in Genetics OSCC inflammation-related indicators prognostic nutritional index (PNI) advanced lung cancer inflammation index (ALI) prognosis prediction |
| title | The comparison of the prognostic value of different inflammation-related indicators in patients with oral squamous cell carcinoma |
| title_full | The comparison of the prognostic value of different inflammation-related indicators in patients with oral squamous cell carcinoma |
| title_fullStr | The comparison of the prognostic value of different inflammation-related indicators in patients with oral squamous cell carcinoma |
| title_full_unstemmed | The comparison of the prognostic value of different inflammation-related indicators in patients with oral squamous cell carcinoma |
| title_short | The comparison of the prognostic value of different inflammation-related indicators in patients with oral squamous cell carcinoma |
| title_sort | comparison of the prognostic value of different inflammation related indicators in patients with oral squamous cell carcinoma |
| topic | OSCC inflammation-related indicators prognostic nutritional index (PNI) advanced lung cancer inflammation index (ALI) prognosis prediction |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2025.1652603/full |
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