Cyclodextrin-based polyrotaxanes: Cellular uptake enhancement effect of different functionality types

Cyclodextrin-based polyrotaxanes: Cellular uptake enhancement effect of different functionality types

Four polyisoprene-based polyrotaxanes (PRX) were synthesized via rotaxa-polymerization and subsequent modification using randomly methylated β-cyclodextrin (RAMEB), hydroxypropyl β-cyclodextrin (HP-βCD), thiolated (HP-βCD-SH), and mercaptosuccinic HP-βCD (HP-βCD-MSA). The polyrotaxanes with threadin...

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Bibliographic Details
Main Authors: David Gintsburg, Pia Kreuzer, Khush Bakhat Afzal, Ilaria Polidori, Martyna Truszkowska, Anna Seybold, Andreas Bernkop-Schnürch, Gergely Kali
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Carbohydrate Polymer Technologies and Applications
Subjects:
Polyrotaxane
Randomly methylated β-cyclodextrin
2-hydroxypropyl β-cyclodextrin
Thiolated β-cyclodextrin
Enzymatic degradation
Cellular uptake
Online Access:http://www.sciencedirect.com/science/article/pii/S2666893925003226
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