Risk assessment and prediction of occult uterine sarcoma in patients with presumed uterine fibroids before high-intensity focused ultrasound treatment
Objective To develop a diagnostic model for predicting occult uterine sarcoma in patients with presumed uterine fibroids.Materials and methods We retrospectively reviewed 41631 patients with presumed uterine fibroids who presented for HIFU treatment in 13 hospitals between November 2008 and October...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2385600 |
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| author | Qian Wang Zhenjiang Lin Xiaogang Zhu Yangyang Wang Ying Zhang Min He Lian Zhang |
| author_facet | Qian Wang Zhenjiang Lin Xiaogang Zhu Yangyang Wang Ying Zhang Min He Lian Zhang |
| author_sort | Qian Wang |
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| description | Objective To develop a diagnostic model for predicting occult uterine sarcoma in patients with presumed uterine fibroids.Materials and methods We retrospectively reviewed 41631 patients with presumed uterine fibroids who presented for HIFU treatment in 13 hospitals between November 2008 and October 2023. Of these patients, 27 with occult uterine sarcoma and 54 with uterine fibroids were enrolled. Univariate analysis and multivariate logistics regression analysis were used to determine the independent risk factors for the diagnosis of occult uterine sarcoma. A prediction model was constructed based on the coefficients of the risk factors.Results The multivariate analysis revealed abnormal vaginal bleeding, ill-defined boundary of tumor, hyperintensity on T2WI, and central unenhanced areas as independent risk factors. A scoring system was created to assess for occult uterine sarcoma risk. The score for abnormal vaginal bleeding was 56. The score for ill-defined lesion boundary was 90. The scores for lesions with hypointensity, isointensity signal/heterogeneous signal intensity, and hyperintensity on T2WI were 0, 42, and 93, respectively. The scores for lesions without enhancement on the mass margin, uniform enhancement of tumor, and no enhancement in the center of tumor were 0, 20, and 100, respectively. Patients with a higher total score implied a higher likelihood of a diagnosis of occult uterine sarcoma than that of patients with a lower score. The established model showed good predictive efficacy.Conclusions Our results demonstrated that the diagnostic prediction model can be used to evaluate the risk of uterine sarcoma in patients with presumed uterine fibroids. |
| format | Article |
| id | doaj-art-f066e50363264ea5bc07ecb91b3834fd |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-f066e50363264ea5bc07ecb91b3834fd2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2385600Risk assessment and prediction of occult uterine sarcoma in patients with presumed uterine fibroids before high-intensity focused ultrasound treatmentQian Wang0Zhenjiang Lin1Xiaogang Zhu2Yangyang Wang3Ying Zhang4Min He5Lian Zhang6State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Obstetrics and Gynaecology, Affiliated Hospital of Zunyi Medical University, Guizhou, ChinaDepartment of Gynaecology, Third Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Gynecology, Chongqing Haifu HospitalState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaObjective To develop a diagnostic model for predicting occult uterine sarcoma in patients with presumed uterine fibroids.Materials and methods We retrospectively reviewed 41631 patients with presumed uterine fibroids who presented for HIFU treatment in 13 hospitals between November 2008 and October 2023. Of these patients, 27 with occult uterine sarcoma and 54 with uterine fibroids were enrolled. Univariate analysis and multivariate logistics regression analysis were used to determine the independent risk factors for the diagnosis of occult uterine sarcoma. A prediction model was constructed based on the coefficients of the risk factors.Results The multivariate analysis revealed abnormal vaginal bleeding, ill-defined boundary of tumor, hyperintensity on T2WI, and central unenhanced areas as independent risk factors. A scoring system was created to assess for occult uterine sarcoma risk. The score for abnormal vaginal bleeding was 56. The score for ill-defined lesion boundary was 90. The scores for lesions with hypointensity, isointensity signal/heterogeneous signal intensity, and hyperintensity on T2WI were 0, 42, and 93, respectively. The scores for lesions without enhancement on the mass margin, uniform enhancement of tumor, and no enhancement in the center of tumor were 0, 20, and 100, respectively. Patients with a higher total score implied a higher likelihood of a diagnosis of occult uterine sarcoma than that of patients with a lower score. The established model showed good predictive efficacy.Conclusions Our results demonstrated that the diagnostic prediction model can be used to evaluate the risk of uterine sarcoma in patients with presumed uterine fibroids.https://www.tandfonline.com/doi/10.1080/02656736.2024.2385600Occult uterine sarcomapresumed uterine fibroidsdiagnostic modelhigh-intensity focused ultrasound ablationMRI features |
| spellingShingle | Qian Wang Zhenjiang Lin Xiaogang Zhu Yangyang Wang Ying Zhang Min He Lian Zhang Risk assessment and prediction of occult uterine sarcoma in patients with presumed uterine fibroids before high-intensity focused ultrasound treatment International Journal of Hyperthermia Occult uterine sarcoma presumed uterine fibroids diagnostic model high-intensity focused ultrasound ablation MRI features |
| title | Risk assessment and prediction of occult uterine sarcoma in patients with presumed uterine fibroids before high-intensity focused ultrasound treatment |
| title_full | Risk assessment and prediction of occult uterine sarcoma in patients with presumed uterine fibroids before high-intensity focused ultrasound treatment |
| title_fullStr | Risk assessment and prediction of occult uterine sarcoma in patients with presumed uterine fibroids before high-intensity focused ultrasound treatment |
| title_full_unstemmed | Risk assessment and prediction of occult uterine sarcoma in patients with presumed uterine fibroids before high-intensity focused ultrasound treatment |
| title_short | Risk assessment and prediction of occult uterine sarcoma in patients with presumed uterine fibroids before high-intensity focused ultrasound treatment |
| title_sort | risk assessment and prediction of occult uterine sarcoma in patients with presumed uterine fibroids before high intensity focused ultrasound treatment |
| topic | Occult uterine sarcoma presumed uterine fibroids diagnostic model high-intensity focused ultrasound ablation MRI features |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2385600 |
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