Benign regulation of short-chain fatty acids: the underlying mechanism of the beneficial effects of manual acupuncture on cognitive ability and the intestinal mucosal barrier in APP/PS1 mice

Benign regulation of short-chain fatty acids: the underlying mechanism of the beneficial effects of manual acupuncture on cognitive ability and the intestinal mucosal barrier in APP/PS1 mice

BackgroundGut microbiota dysbiosis is closely related to the occurrence and progression of Alzheimer’s disease (AD). The destruction of the intestinal mucosal barrier caused by a decrease in short-chain fatty acids (SCFAs) plays a key role in gut microbiota dysbiosis-induced neuroinflammation in AD....

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Bibliographic Details
Main Authors: Ning Ding, Xin Hao, Yue Zhang, Yanxiang Zhang, Zhigang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Neuroscience
Subjects:
manual acupuncture
Alzheimer’s disease
short chain fatty acids (SCFAs)
FFAR3
intestinal mucosal barrier
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1509581/full
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