Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species
Abstract Angelica L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies have focused on the metabolomic differences among the Angelica species. In this study, widely targeted metabolomics based on gas chromatography-tandem mass spectrometry w...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | Natural Products and Bioprospecting |
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| Online Access: | https://doi.org/10.1007/s13659-024-00485-5 |
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| author | Jiaojiao Ji Lanlan Zang Tingting Lu Cheng Li Xiaoxu Han Soo-Rang Lee Li Wang |
| author_facet | Jiaojiao Ji Lanlan Zang Tingting Lu Cheng Li Xiaoxu Han Soo-Rang Lee Li Wang |
| author_sort | Jiaojiao Ji |
| collection | DOAJ |
| description | Abstract Angelica L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies have focused on the metabolomic differences among the Angelica species. In this study, widely targeted metabolomics based on gas chromatography-tandem mass spectrometry was employed to analyze the metabolomes of four Angelica species (Angelica sinensis (Oliv.) Diels (A. sinensis), Angelica biserrata (R.H.Shan & Yuan) C.Q.Yuan & R.H.Shan (A. biserrata), Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. (A. dahurica) and Angelica keiskei Koidz. (A. keiskei)). A total of 698 volatile metabolites were identified and classified into fifteen different categories. The metabolomic analysis indicated that 7-hydroxycoumarin and Z-ligustilide accumulated at significantly higher levels in A. sinensis, whereas bornyl acetate showed the opposite pattern. Furthermore, a high correspondence between the dendrogram of metabolite contents and phylogenetic positions of the four species. This study provides a comprehensive biochemical map for the exploitation, application and development of the Angelica species as medicinal plants or health-related dietary supplements. Graphical Abstract |
| format | Article |
| id | doaj-art-f037ecb495f441bf9e53403449f96033 |
| institution | Kabale University |
| issn | 2192-2195 2192-2209 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
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| series | Natural Products and Bioprospecting |
| spelling | doaj-art-f037ecb495f441bf9e53403449f960332025-01-05T12:49:57ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092025-01-0115111310.1007/s13659-024-00485-5Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica speciesJiaojiao Ji0Lanlan Zang1Tingting Lu2Cheng Li3Xiaoxu Han4Soo-Rang Lee5Li Wang6Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural SciencesShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural SciencesShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural SciencesShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural SciencesShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural SciencesDepartment of Biology Education, College of Education, Chosun UniversityShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural SciencesAbstract Angelica L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies have focused on the metabolomic differences among the Angelica species. In this study, widely targeted metabolomics based on gas chromatography-tandem mass spectrometry was employed to analyze the metabolomes of four Angelica species (Angelica sinensis (Oliv.) Diels (A. sinensis), Angelica biserrata (R.H.Shan & Yuan) C.Q.Yuan & R.H.Shan (A. biserrata), Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. (A. dahurica) and Angelica keiskei Koidz. (A. keiskei)). A total of 698 volatile metabolites were identified and classified into fifteen different categories. The metabolomic analysis indicated that 7-hydroxycoumarin and Z-ligustilide accumulated at significantly higher levels in A. sinensis, whereas bornyl acetate showed the opposite pattern. Furthermore, a high correspondence between the dendrogram of metabolite contents and phylogenetic positions of the four species. This study provides a comprehensive biochemical map for the exploitation, application and development of the Angelica species as medicinal plants or health-related dietary supplements. Graphical Abstracthttps://doi.org/10.1007/s13659-024-00485-5AngelicaVolatile metabolitesChinese traditional medicinePhylogeny |
| spellingShingle | Jiaojiao Ji Lanlan Zang Tingting Lu Cheng Li Xiaoxu Han Soo-Rang Lee Li Wang Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species Natural Products and Bioprospecting Angelica Volatile metabolites Chinese traditional medicine Phylogeny |
| title | Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species |
| title_full | Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species |
| title_fullStr | Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species |
| title_full_unstemmed | Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species |
| title_short | Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species |
| title_sort | widely targeted metabolomics analysis reveals differences in volatile metabolites among four angelica species |
| topic | Angelica Volatile metabolites Chinese traditional medicine Phylogeny |
| url | https://doi.org/10.1007/s13659-024-00485-5 |
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