Clinical impacts of Artocarpus lakoocha agglutinin-binding glycans for prognosis and treatment of cholangiocarcinoma

Clinical impacts of Artocarpus lakoocha agglutinin-binding glycans for prognosis and treatment of cholangiocarcinoma

Abstract Artocarpus lakoocha agglutinin (ALA), which specifically targets the Gal/GalNAc components of complex glycans, was isolated from the seeds of Artocarpus lakoocha. This study is the first to explore the role of ALA in identifying aberrant glycans, designated ALA-binding glycans (ALAG), and i...

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Main Authors: Phisit Sintusen, Kulthida Vaeteewoottacharn, Ubon Cha’on, Chawalit Pairojkul, Chaiwat Aphivatanasiri, Sutas Suttiprapa, Panupong Mahalapbutr, Atit Silsirivanit, Sopit Wongkham, Sukanya Luang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Artocarpus lakoocha agglutinin
Cholangiocarcinoma
Aberrant glycosylation
T and Tn antigens
Anti-metastasis
Anti-proliferation
Online Access:https://doi.org/10.1038/s41598-024-84444-7
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