Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis
Histo-morphological alterations observed at mucosal surgical margins can be envisaged as potential markers of malignant transformation. In this paper, we have presented a very striking observation at the mucosal surgical margins of oral squamous cell carcinoma arising in the background of oral submu...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426821000385 |
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| author | Sachin C. Sarode Gargi S. Sarode Namrata Sengupta Urmi Ghone Shankargouda Patil |
| author_facet | Sachin C. Sarode Gargi S. Sarode Namrata Sengupta Urmi Ghone Shankargouda Patil |
| author_sort | Sachin C. Sarode |
| collection | DOAJ |
| description | Histo-morphological alterations observed at mucosal surgical margins can be envisaged as potential markers of malignant transformation. In this paper, we have presented a very striking observation at the mucosal surgical margins of oral squamous cell carcinoma arising in the background of oral submucous fibrosis (OSCC-OSMF). Out of 38 cases of OSCC-OSMF, 22 (57.89%) showed conspicuous large dilated vascular spaces lined by endothelial cells in the background of dense fibrosis. These large dilated areas were engorged with red blood cells and were located at the juxta-epithelial and submucosal regions. Since surgical margin tissues are biologically close to malignant transformation, we proposed this unique feature as a potential predictive marker for oral submucous fibrosis that will aid in the early detection of OSCC. Future cohort studies are warranted to prove the authenticity of the present observations. |
| format | Article |
| id | doaj-art-f01f641d6c2641c9828f59ab75a58106 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-f01f641d6c2641c9828f59ab75a581062024-11-23T06:28:44ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682021-07-01113365367Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosisSachin C. Sarode0Gargi S. Sarode1Namrata Sengupta2Urmi Ghone3Shankargouda Patil4Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, 411018, MH, India; Corresponding author.Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, 411018, MH, IndiaDepartment of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, 411018, MH, IndiaDepartment of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, 411018, MH, IndiaDepartment of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi ArabiaHisto-morphological alterations observed at mucosal surgical margins can be envisaged as potential markers of malignant transformation. In this paper, we have presented a very striking observation at the mucosal surgical margins of oral squamous cell carcinoma arising in the background of oral submucous fibrosis (OSCC-OSMF). Out of 38 cases of OSCC-OSMF, 22 (57.89%) showed conspicuous large dilated vascular spaces lined by endothelial cells in the background of dense fibrosis. These large dilated areas were engorged with red blood cells and were located at the juxta-epithelial and submucosal regions. Since surgical margin tissues are biologically close to malignant transformation, we proposed this unique feature as a potential predictive marker for oral submucous fibrosis that will aid in the early detection of OSCC. Future cohort studies are warranted to prove the authenticity of the present observations.http://www.sciencedirect.com/science/article/pii/S2212426821000385Oral squamous cell carcinomaOral submucous fibrosisMalignant transformationPredictive biomarker |
| spellingShingle | Sachin C. Sarode Gargi S. Sarode Namrata Sengupta Urmi Ghone Shankargouda Patil Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis Journal of Oral Biology and Craniofacial Research Oral squamous cell carcinoma Oral submucous fibrosis Malignant transformation Predictive biomarker |
| title | Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis |
| title_full | Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis |
| title_fullStr | Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis |
| title_full_unstemmed | Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis |
| title_short | Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis |
| title_sort | conspicuous and frank dilated vascular spaces a marker of malignant transformation in oral submucous fibrosis |
| topic | Oral squamous cell carcinoma Oral submucous fibrosis Malignant transformation Predictive biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S2212426821000385 |
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