Loss of phosphatase and tensin homolog (PTEN) increases Lysyl oxidase-like 2 (LOXL2) expression enhancing the growth of fallopian tube epithelial cells as three-dimensional spheroids

Loss of phosphatase and tensin homolog (PTEN) increases Lysyl oxidase-like 2 (LOXL2) expression enhancing the growth of fallopian tube epithelial cells as three-dimensional spheroids

Background: High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of all ovarian cancer-related deaths. Multiple studies have suggested that the fallopian tube epithelium (FTE) serves as the cell of origin of HGSOC. Phosphatase and tensin homolog (PTEN) is a tumor suppressor and its loss is s...

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Bibliographic Details
Main Authors: Angela Russo, Junlone Moy, Manead Khin, Timothy R. Dorsey, Alfredo Lopez Carrero, Joanna E. Burdette
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cancer Pathogenesis and Therapy
Subjects:
LOXL2
PTEN
PAX2
Fallopian tube
Ovarian cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2949713224000223
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