Impaired theta and low-gamma directed information flow in the hippocampal-prefrontal circuit underlies working memory deficits in APP/PS1 mice

Impaired theta and low-gamma directed information flow in the hippocampal-prefrontal circuit underlies working memory deficits in APP/PS1 mice

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline. Working memory impairment, a hallmark of early-stage AD, is hypothesized to arise from deficits in encoding processes. Given the critical role of hippocampal-prefrontal interactions in w...

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Bibliographic Details
Main Authors: Hongrui Ai, Shengnan Zhang, Chengbo Si, Tiaotiao Liu, Xuyuan Zheng, Xin Tian, Wenwen Bai
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Behavioral and Brain Functions
Subjects:
Alzheimer’s disease
Working memory
Encoding phase
Hippocampal-prefrontal circuit
Online Access:https://doi.org/10.1186/s12993-025-00285-y
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