Piezo1-mediated mechanotransduction regulates the translational activity, function and lung pathogenicity of group 2 innate lymphoid cells

Piezo1-mediated mechanotransduction regulates the translational activity, function and lung pathogenicity of group 2 innate lymphoid cells

Abstract Group 2 innate lymphoid cells (ILC2s) are central effectors of type 2 immune responses in the lung; however, how mechanical cues regulate their function remains unclear. Here, we identified the mechanosensitive ion channel Piezo1 as a key regulator of ILC2 effector function through translat...

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Main Authors: MinYeong Lim, Seonjun Park, Yoon Ha Joo, Sung Eun Kim, Min Hee Ham, TaeSoo Kim, Kihyuck Kwak, Sung Joon Kim, Jung Chan Lee, Sung Ho Park, Hye Young Kim
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02350-4
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https://doi.org/10.1038/s41392-025-02350-4

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