Metabolic landscape uncovers remodeling of T cell immunity affected by fatty acid desaturase in Parkinson’s disease at single-cell resolution

Metabolic landscape uncovers remodeling of T cell immunity affected by fatty acid desaturase in Parkinson’s disease at single-cell resolution

Abstract Background Peripheral activated T cells cross the blood–brain barrier, partake in neuroinflammation, and induce dopaminergic neuron degeneration through characteristics such as cell adhesion and immune response in Parkinson’s disease (PD). Metabolic activity, which can regulate and be regul...

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Bibliographic Details
Main Authors: Shi Yan, Xue Zhao, Yao Si, Xinyu Zhang, Di Wang, Lifen Yao, Linlin Sun
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Biology
Subjects:
Parkinson’s disease
T cells
Metabolic reprogramming
scRNA-seq
Unsaturated fatty acid biosynthetic process
Online Access:https://doi.org/10.1186/s12915-025-02358-w
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