Prolonged exposure to insulin might cause epigenetic alteration leading to insulin resistance

Prolonged exposure to insulin might cause epigenetic alteration leading to insulin resistance

Glucose homeostasis is maintained by insulin. Insulin resistance is caused by multiple factors including hereditary factors and diet. The molecular mechanism underlying insulin resistance (IR) is not completely understood. Hyperinsulinemia often precedes insulin resistance and Type 2 diabetes. We ha...

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Bibliographic Details
Main Authors: Shehnaz Bano, Shyam More, Dattatray S. Mongad, Abdul Khalique, Dhiraj P. Dhotre, Manoj K. Bhat, Vasudevan Seshadri
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:FEBS Open Bio
Subjects:
epigenetic modifiers
histone methylation
insulin resistance
mouse model
RNA‐sequencing
Online Access:https://doi.org/10.1002/2211-5463.13891
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