A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells

Abstract DNA replication stress is a hallmark of cancer that is exploited by chemotherapies. Current assays for replication stress have low throughput and poor resolution whilst being unable to map the movement of replication forks genome-wide. We present a new method that uses nanopore sequencing a...

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Main Authors: Mathew J. K. Jones, Subash Kumar Rai, Pauline L. Pfuderer, Alexis Bonfim-Melo, Julia K. Pagan, Paul R. Clarke, Francis Isidore Garcia Totañes, Catherine J. Merrick, Sarah E. McClelland, Michael A. Boemo
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63168-w
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https://doi.org/10.1038/s41467-025-63168-w

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