An improved ultrasound-assisted synthesis of phenytoin suitable for undergraduate education
A convenient and efficient method for undergraduate student experiments involves the one-pot synthesis of phenytoin from benzoin. This method utilized ultrasonic irradiation in the presence of basic catalyst at room temperature and atmospheric pressure, resulting in shortened reaction times, good yi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
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| Series: | Ultrasonics Sonochemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417724004565 |
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| _version_ | 1841546024284323840 |
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| author | Baowei Yang Xiandong Zhai Runzhe Mei Pu Wang Yicheng Mei |
| author_facet | Baowei Yang Xiandong Zhai Runzhe Mei Pu Wang Yicheng Mei |
| author_sort | Baowei Yang |
| collection | DOAJ |
| description | A convenient and efficient method for undergraduate student experiments involves the one-pot synthesis of phenytoin from benzoin. This method utilized ultrasonic irradiation in the presence of basic catalyst at room temperature and atmospheric pressure, resulting in shortened reaction times, good yields, and excellent reproducibility. By employing a low-cost ultrasonic cleaner for ultrasonic irradiation in student experiments, the need for expensive equipment investment during the teaching process can be minimized. Consequently, this approach is suitable for widespread promotion and application in undergraduate education. |
| format | Article |
| id | doaj-art-ef1575f5b2cf4ae3a726d9ce4691344e |
| institution | Kabale University |
| issn | 1350-4177 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj-art-ef1575f5b2cf4ae3a726d9ce4691344e2025-01-11T06:38:51ZengElsevierUltrasonics Sonochemistry1350-41772025-01-01112107207An improved ultrasound-assisted synthesis of phenytoin suitable for undergraduate educationBaowei Yang0Xiandong Zhai1Runzhe Mei2Pu Wang3Yicheng Mei4School of Pharmacy, Jiangsu Food & Pharmaceutical Science College, Huaian, Jiangsu 223003, PR ChinaSchool of Pharmaceutical Engineering, Jiangsu Food & Pharmaceutical Science College, Huaian, Jiangsu 223003, PR ChinaDepartment of Mechanical and Aerospace Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, ChinaCollege of Life Sciences, Northeast Forestry University, Harbin, Heilongjiang 150040, PR ChinaSchool of Pharmaceutical Engineering, Jiangsu Food & Pharmaceutical Science College, Huaian, Jiangsu 223003, PR China; Corresponding author.A convenient and efficient method for undergraduate student experiments involves the one-pot synthesis of phenytoin from benzoin. This method utilized ultrasonic irradiation in the presence of basic catalyst at room temperature and atmospheric pressure, resulting in shortened reaction times, good yields, and excellent reproducibility. By employing a low-cost ultrasonic cleaner for ultrasonic irradiation in student experiments, the need for expensive equipment investment during the teaching process can be minimized. Consequently, this approach is suitable for widespread promotion and application in undergraduate education.http://www.sciencedirect.com/science/article/pii/S1350417724004565SonochemistryUltrasound-assisted synthesisPhenytoinOne-pot synthesisUndergraduate education |
| spellingShingle | Baowei Yang Xiandong Zhai Runzhe Mei Pu Wang Yicheng Mei An improved ultrasound-assisted synthesis of phenytoin suitable for undergraduate education Ultrasonics Sonochemistry Sonochemistry Ultrasound-assisted synthesis Phenytoin One-pot synthesis Undergraduate education |
| title | An improved ultrasound-assisted synthesis of phenytoin suitable for undergraduate education |
| title_full | An improved ultrasound-assisted synthesis of phenytoin suitable for undergraduate education |
| title_fullStr | An improved ultrasound-assisted synthesis of phenytoin suitable for undergraduate education |
| title_full_unstemmed | An improved ultrasound-assisted synthesis of phenytoin suitable for undergraduate education |
| title_short | An improved ultrasound-assisted synthesis of phenytoin suitable for undergraduate education |
| title_sort | improved ultrasound assisted synthesis of phenytoin suitable for undergraduate education |
| topic | Sonochemistry Ultrasound-assisted synthesis Phenytoin One-pot synthesis Undergraduate education |
| url | http://www.sciencedirect.com/science/article/pii/S1350417724004565 |
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