Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure
Abstract People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance ima...
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-55911-0 |
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| author | Tess E. Peterson Virginia S. Hahn Ruin Moaddel Min Zhu Sabina A. Haberlen Frank J. Palella Michael Plankey Joel S. Bader Joao A. C. Lima Robert E. Gerszten Jerome I. Rotter Stephen S. Rich Susan R. Heckbert Gregory D. Kirk Damani A. Piggott Luigi Ferrucci Joseph B. Margolick Todd T. Brown Katherine C. Wu Wendy S. Post |
| author_facet | Tess E. Peterson Virginia S. Hahn Ruin Moaddel Min Zhu Sabina A. Haberlen Frank J. Palella Michael Plankey Joel S. Bader Joao A. C. Lima Robert E. Gerszten Jerome I. Rotter Stephen S. Rich Susan R. Heckbert Gregory D. Kirk Damani A. Piggott Luigi Ferrucci Joseph B. Margolick Todd T. Brown Katherine C. Wu Wendy S. Post |
| author_sort | Tess E. Peterson |
| collection | DOAJ |
| description | Abstract People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure. We discover a plasma proteomic signature that may in part reflect or contribute to HIV-associated atrial remodeling, many features of which are associated with older age and time to incident heart failure among an independent community-based cohort without HIV. This proteomic profile was statistically enriched for immune checkpoint proteins, tumor necrosis factor signaling, ephrin signaling, and extracellular matrix organization, identifying possible shared pathways in HIV and aging that may contribute to risk of heart failure. |
| format | Article |
| id | doaj-art-ef067b1a63a74a149f658630043b87a9 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-ef067b1a63a74a149f658630043b87a92025-01-12T12:30:50ZengNature PortfolioNature Communications2041-17232025-01-0116111310.1038/s41467-025-55911-0Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failureTess E. Peterson0Virginia S. Hahn1Ruin Moaddel2Min Zhu3Sabina A. Haberlen4Frank J. Palella5Michael Plankey6Joel S. Bader7Joao A. C. Lima8Robert E. Gerszten9Jerome I. Rotter10Stephen S. Rich11Susan R. Heckbert12Gregory D. Kirk13Damani A. Piggott14Luigi Ferrucci15Joseph B. Margolick16Todd T. Brown17Katherine C. Wu18Wendy S. Post19Division of Cardiology, Department of Medicine, Johns Hopkins UniversityDivision of Cardiology, Department of Medicine, Johns Hopkins UniversityBiomedical Research Centre, National Institute on Aging, NIHBiomedical Research Centre, National Institute on Aging, NIHDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public HealthDepartment of Medicine, Northwestern University Feinberg School of MedicineDivision of General Internal Medicine, Department of Medicine, Georgetown UniversityDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins UniversityDivision of Cardiology, Department of Medicine, Johns Hopkins UniversityDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical CenterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterDepartment of Genome Sciences, University of VirginiaDepartment of Epidemiology, University of Washington School of Public HealthDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public HealthDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public HealthBiomedical Research Centre, National Institute on Aging, NIHDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public HealthDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public HealthDivision of Cardiology, Department of Medicine, Johns Hopkins UniversityDivision of Cardiology, Department of Medicine, Johns Hopkins UniversityAbstract People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure. We discover a plasma proteomic signature that may in part reflect or contribute to HIV-associated atrial remodeling, many features of which are associated with older age and time to incident heart failure among an independent community-based cohort without HIV. This proteomic profile was statistically enriched for immune checkpoint proteins, tumor necrosis factor signaling, ephrin signaling, and extracellular matrix organization, identifying possible shared pathways in HIV and aging that may contribute to risk of heart failure.https://doi.org/10.1038/s41467-025-55911-0 |
| spellingShingle | Tess E. Peterson Virginia S. Hahn Ruin Moaddel Min Zhu Sabina A. Haberlen Frank J. Palella Michael Plankey Joel S. Bader Joao A. C. Lima Robert E. Gerszten Jerome I. Rotter Stephen S. Rich Susan R. Heckbert Gregory D. Kirk Damani A. Piggott Luigi Ferrucci Joseph B. Margolick Todd T. Brown Katherine C. Wu Wendy S. Post Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure Nature Communications |
| title | Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure |
| title_full | Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure |
| title_fullStr | Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure |
| title_full_unstemmed | Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure |
| title_short | Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure |
| title_sort | proteomic signature of hiv associated subclinical left atrial remodeling and incident heart failure |
| url | https://doi.org/10.1038/s41467-025-55911-0 |
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