PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation

PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation

Abstract Background Oocyte maturation defect (OMD) and early embryonic arrest result in female infertility. Previous studies have linked biallelic mutations in the PATL2 gene to OMD, yet the underlying mechanism remains largely unknown. Results This study uncovers three novel mutations (c.1201G >...

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Bibliographic Details
Main Authors: Yin-Li Zhang, Zhanhong Hu, Huifang Jiang, Jiamin Jin, Yan Zhou, Mengru Lai, Peipei Ren, Siya Liu, Ying-Yi Zhang, Yan Rong, Wei Zheng, Shen Zhang, Xiaomei Tong, Songying Zhang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell & Bioscience
Subjects:
PATL2 mutation
TUT7
CDC23
mRNA storage
mRNA decay
Online Access:https://doi.org/10.1186/s13578-024-01341-2
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