Analysis of fetal fraction in non-invasive prenatal testing with low-depth whole genome sequencing

Analysis of fetal fraction in non-invasive prenatal testing with low-depth whole genome sequencing

Background: The fetal fraction (FF) is a critical factor influencing the performance of non-invasive prenatal testing (NIPT). Different NIPT methods and sequencing depths can lead to distinct minimum FF thresholds for Trisomy 21 (T21). This study aims to analyze the minimum FF thresholds for detecti...

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Bibliographic Details
Main Authors: Xiaolei Xie, Weiguo Yin, Fuguang Li, Suxia Xuan, Yu Ouyang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
Cell-free DNA
Fetal fraction
NIPT
Maternal weight
Trisomy 21
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024175949
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