Age but not vitamin D is related to sarcopenia in vitamin D sufficient male elderly in rural China
Abstract This study aimed to identify the correlation of serum 25(OH)D level with sarcopenia and its components in Chinese elderly aged 65 years and above from rural areas. A total of 368 Chinese elderly aged 65 years and above in rural areas were enrolled. Indicators of muscle mass and strength, in...
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2025-01-01
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author | Weinuo Mi Huifeng Zhang Lina Zhang Xingjia Li Zhiguo Wang Yu Sun Tonggao Shen Kuanlu Fan Chao Liu Shuhang Xu |
author_facet | Weinuo Mi Huifeng Zhang Lina Zhang Xingjia Li Zhiguo Wang Yu Sun Tonggao Shen Kuanlu Fan Chao Liu Shuhang Xu |
author_sort | Weinuo Mi |
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description | Abstract This study aimed to identify the correlation of serum 25(OH)D level with sarcopenia and its components in Chinese elderly aged 65 years and above from rural areas. A total of 368 Chinese elderly aged 65 years and above in rural areas were enrolled. Indicators of muscle mass and strength, including the appendicular skeletal muscle mass (ASM), skeletal muscle index (SMI) and hand grip strength (HGS) were measured. Physical performance was assessed by the Short Physical Performance Battery (SPPB). Serum 25(OH)D levels were measured using the liquid chromatography with tandem mass spectrometry. Correlations of serum 25(OH)D level with sarcopenia and its components in Chinese elderly were identified by the binary logistic regression and linear regression analyses. The median serum 25(OH)D level was 34.80 ng/ml, and significantly higher in men than in women (40.70 ng/ml vs. 27.30 ng/ml). The prevalence of sarcopenia in our cohort was 21.5%, and higher in men than in women (29.4% vs. 10.8%). The serum 25(OH)D level was not correlated with sarcopenia, HGS and SPPB score in either male or female elderly. Positive correlations of age with sarcopenia, low HGS and low SPPB score were observed in male elderly, while significant correlations were not observed in females. Correlation analyses of sarcopenia components revealed that age was negatively correlated with SMI and gait speed in male elderly, but negatively correlated with the gait speed and positively correlated with the time to complete 5 sit-to-stand movements in female elderly. In conclusion, rural Chinese elderly have relatively high vitamin D level and prevalence of sarcopenia. Age but not serum 25(OH)D level is significantly correlated with sarcopenia in vitamin D sufficient male elderly. |
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spelling | doaj-art-eec10c17c3cf41e2858ab9b00254ff192025-01-05T12:14:53ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-025-85468-3Age but not vitamin D is related to sarcopenia in vitamin D sufficient male elderly in rural ChinaWeinuo Mi0Huifeng Zhang1Lina Zhang2Xingjia Li3Zhiguo Wang4Yu Sun5Tonggao Shen6Kuanlu Fan7Chao Liu8Shuhang Xu9Department of Endocrinology, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Endocrinology, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Endocrinology, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Endocrinology, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineClinical Laboratory, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineThe Affiliated Suqian Hospital of Xuzhou Medical UniversityDiabetes and Endocrinology Hospital of Suining CountyDepartment of Endocrinology, The Second Affiliated Hospital of Xuzhou Medical UniversityDepartment of Endocrinology, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Endocrinology, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineAbstract This study aimed to identify the correlation of serum 25(OH)D level with sarcopenia and its components in Chinese elderly aged 65 years and above from rural areas. A total of 368 Chinese elderly aged 65 years and above in rural areas were enrolled. Indicators of muscle mass and strength, including the appendicular skeletal muscle mass (ASM), skeletal muscle index (SMI) and hand grip strength (HGS) were measured. Physical performance was assessed by the Short Physical Performance Battery (SPPB). Serum 25(OH)D levels were measured using the liquid chromatography with tandem mass spectrometry. Correlations of serum 25(OH)D level with sarcopenia and its components in Chinese elderly were identified by the binary logistic regression and linear regression analyses. The median serum 25(OH)D level was 34.80 ng/ml, and significantly higher in men than in women (40.70 ng/ml vs. 27.30 ng/ml). The prevalence of sarcopenia in our cohort was 21.5%, and higher in men than in women (29.4% vs. 10.8%). The serum 25(OH)D level was not correlated with sarcopenia, HGS and SPPB score in either male or female elderly. Positive correlations of age with sarcopenia, low HGS and low SPPB score were observed in male elderly, while significant correlations were not observed in females. Correlation analyses of sarcopenia components revealed that age was negatively correlated with SMI and gait speed in male elderly, but negatively correlated with the gait speed and positively correlated with the time to complete 5 sit-to-stand movements in female elderly. In conclusion, rural Chinese elderly have relatively high vitamin D level and prevalence of sarcopenia. Age but not serum 25(OH)D level is significantly correlated with sarcopenia in vitamin D sufficient male elderly.https://doi.org/10.1038/s41598-025-85468-3Vitamin DElderlySarcopeniaHand grip strengthPhysical performanceAge |
spellingShingle | Weinuo Mi Huifeng Zhang Lina Zhang Xingjia Li Zhiguo Wang Yu Sun Tonggao Shen Kuanlu Fan Chao Liu Shuhang Xu Age but not vitamin D is related to sarcopenia in vitamin D sufficient male elderly in rural China Scientific Reports Vitamin D Elderly Sarcopenia Hand grip strength Physical performance Age |
title | Age but not vitamin D is related to sarcopenia in vitamin D sufficient male elderly in rural China |
title_full | Age but not vitamin D is related to sarcopenia in vitamin D sufficient male elderly in rural China |
title_fullStr | Age but not vitamin D is related to sarcopenia in vitamin D sufficient male elderly in rural China |
title_full_unstemmed | Age but not vitamin D is related to sarcopenia in vitamin D sufficient male elderly in rural China |
title_short | Age but not vitamin D is related to sarcopenia in vitamin D sufficient male elderly in rural China |
title_sort | age but not vitamin d is related to sarcopenia in vitamin d sufficient male elderly in rural china |
topic | Vitamin D Elderly Sarcopenia Hand grip strength Physical performance Age |
url | https://doi.org/10.1038/s41598-025-85468-3 |
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