The Role of the Intestinal Context in the Generation of Tolerance and Inflammation
The mucosal surface of the intestine alone forms the largest area exposed to exogenous antigens as well as the largest collection of lymphoid tissue in the body. The enormous amount of nonpathogenic and pathogenic bacteria and food-derived antigens that we are daily exposed sets an interesting chall...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/157948 |
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| _version_ | 1841524581469257728 |
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| author | Bernardo Sgarbi Reis Daniel Mucida |
| author_facet | Bernardo Sgarbi Reis Daniel Mucida |
| author_sort | Bernardo Sgarbi Reis |
| collection | DOAJ |
| description | The mucosal surface of the intestine alone forms the largest area exposed to exogenous antigens as well as the largest collection of lymphoid tissue in the body. The enormous amount of nonpathogenic and pathogenic bacteria and food-derived antigens that we are daily exposed sets an interesting challenge to the immune system: a protective immune activity must coexist with efficient regulatory mechanisms in order to maintain a health status of these organisms. This paper discusses how the immune system assimilates the perturbations from the environment without generating tissue damage. |
| format | Article |
| id | doaj-art-eeb76465ddba48e7b0045ff941c4083f |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-eeb76465ddba48e7b0045ff941c4083f2025-02-03T05:52:55ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/157948157948The Role of the Intestinal Context in the Generation of Tolerance and InflammationBernardo Sgarbi Reis0Daniel Mucida1Laboratory of Mucosal Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USALaboratory of Mucosal Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USAThe mucosal surface of the intestine alone forms the largest area exposed to exogenous antigens as well as the largest collection of lymphoid tissue in the body. The enormous amount of nonpathogenic and pathogenic bacteria and food-derived antigens that we are daily exposed sets an interesting challenge to the immune system: a protective immune activity must coexist with efficient regulatory mechanisms in order to maintain a health status of these organisms. This paper discusses how the immune system assimilates the perturbations from the environment without generating tissue damage.http://dx.doi.org/10.1155/2012/157948 |
| spellingShingle | Bernardo Sgarbi Reis Daniel Mucida The Role of the Intestinal Context in the Generation of Tolerance and Inflammation Clinical and Developmental Immunology |
| title | The Role of the Intestinal Context in the Generation of Tolerance and Inflammation |
| title_full | The Role of the Intestinal Context in the Generation of Tolerance and Inflammation |
| title_fullStr | The Role of the Intestinal Context in the Generation of Tolerance and Inflammation |
| title_full_unstemmed | The Role of the Intestinal Context in the Generation of Tolerance and Inflammation |
| title_short | The Role of the Intestinal Context in the Generation of Tolerance and Inflammation |
| title_sort | role of the intestinal context in the generation of tolerance and inflammation |
| url | http://dx.doi.org/10.1155/2012/157948 |
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