Investigating the genetic landscape of cancer in Jordan: a step toward personalized care
Abstract Cancer is a leading cause of mortality worldwide, with genetic predispositions playing a key role in disease onset. This review assessed over 80 published genetic studies involving more than 3000 Jordanian cancer patients to explore the hereditary landscape of cancer in Jordan. Breast, colo...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02799-7 |
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| author | Laith N. AL-Eitan Amneh H. Tarkhan Haneen O. Ali Maryam K. Alasmar Mansour A. Alghamdi |
| author_facet | Laith N. AL-Eitan Amneh H. Tarkhan Haneen O. Ali Maryam K. Alasmar Mansour A. Alghamdi |
| author_sort | Laith N. AL-Eitan |
| collection | DOAJ |
| description | Abstract Cancer is a leading cause of mortality worldwide, with genetic predispositions playing a key role in disease onset. This review assessed over 80 published genetic studies involving more than 3000 Jordanian cancer patients to explore the hereditary landscape of cancer in Jordan. Breast, colorectal, and lung cancers were the most studied, with BRCA1/2 and TP53 among the most frequently mutated genes. While somatic mutations such as KRAS and EGFR were commonly reported in tumor studies, our primary focus is on germline PSVs that may indicate population-specific genetic risks, including BRCA1 exon 11 mutations in breast cancer and p.Gly12Asp in KRAS for colorectal cancer. Unique or novel PSVs, particularly in BRCA2 and AKT1, were also reported, suggesting potential founder effects or region-specific genetic risks. These findings support integrating multigene panel testing and genetic counseling into national cancer prevention strategies to improve early detection and personalized care in Jordan. |
| format | Article |
| id | doaj-art-eea93f1e6f1d4842a41318b4f779b15d |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-eea93f1e6f1d4842a41318b4f779b15d2025-08-20T03:45:24ZengBMCEuropean Journal of Medical Research2047-783X2025-07-013011910.1186/s40001-025-02799-7Investigating the genetic landscape of cancer in Jordan: a step toward personalized careLaith N. AL-Eitan0Amneh H. Tarkhan1Haneen O. Ali2Maryam K. Alasmar3Mansour A. Alghamdi4Department of Biotechnology and Genetic Engineering, Jordan University of Science and TechnologyDepartment of Biotechnology and Genetic Engineering, Jordan University of Science and TechnologyDepartment of Biotechnology and Genetic Engineering, Jordan University of Science and TechnologyDepartment of Biotechnology and Genetic Engineering, Jordan University of Science and TechnologyDepartment of Anatomy, College of Medicine, King Khalid UniversityAbstract Cancer is a leading cause of mortality worldwide, with genetic predispositions playing a key role in disease onset. This review assessed over 80 published genetic studies involving more than 3000 Jordanian cancer patients to explore the hereditary landscape of cancer in Jordan. Breast, colorectal, and lung cancers were the most studied, with BRCA1/2 and TP53 among the most frequently mutated genes. While somatic mutations such as KRAS and EGFR were commonly reported in tumor studies, our primary focus is on germline PSVs that may indicate population-specific genetic risks, including BRCA1 exon 11 mutations in breast cancer and p.Gly12Asp in KRAS for colorectal cancer. Unique or novel PSVs, particularly in BRCA2 and AKT1, were also reported, suggesting potential founder effects or region-specific genetic risks. These findings support integrating multigene panel testing and genetic counseling into national cancer prevention strategies to improve early detection and personalized care in Jordan.https://doi.org/10.1186/s40001-025-02799-7JordanCancerGeneticsEarly screeningGenetic testing |
| spellingShingle | Laith N. AL-Eitan Amneh H. Tarkhan Haneen O. Ali Maryam K. Alasmar Mansour A. Alghamdi Investigating the genetic landscape of cancer in Jordan: a step toward personalized care European Journal of Medical Research Jordan Cancer Genetics Early screening Genetic testing |
| title | Investigating the genetic landscape of cancer in Jordan: a step toward personalized care |
| title_full | Investigating the genetic landscape of cancer in Jordan: a step toward personalized care |
| title_fullStr | Investigating the genetic landscape of cancer in Jordan: a step toward personalized care |
| title_full_unstemmed | Investigating the genetic landscape of cancer in Jordan: a step toward personalized care |
| title_short | Investigating the genetic landscape of cancer in Jordan: a step toward personalized care |
| title_sort | investigating the genetic landscape of cancer in jordan a step toward personalized care |
| topic | Jordan Cancer Genetics Early screening Genetic testing |
| url | https://doi.org/10.1186/s40001-025-02799-7 |
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