Idiopathic Distal Sensory Polyneuropathy and Fibromyalgia Syndrome: A Comparative Phenotyping Study
Abstract Introduction Painful idiopathic distal sensory polyneuropathy (IDSP) and fibromyalgia syndrome (FMS) are cryptogenic chronic pain syndromes. The contribution of small fibre pathology (SFP) in FMS remains controversial. This study aims to quantify small nerve pathology in participants with I...
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| Language: | English |
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Adis, Springer Healthcare
2024-09-01
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| Series: | Pain and Therapy |
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| Online Access: | https://doi.org/10.1007/s40122-024-00646-x |
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| author | Jamie Burgess Anne Marshall Leandros Rapteas David Riley Kohei Matsumoto Cheng Boon Alia Alchawaf Maryam Ferdousi Rayaz A. Malik Andrew Marshall Stephen Kaye David Gosal Bernhard Frank Uazman Alam |
| author_facet | Jamie Burgess Anne Marshall Leandros Rapteas David Riley Kohei Matsumoto Cheng Boon Alia Alchawaf Maryam Ferdousi Rayaz A. Malik Andrew Marshall Stephen Kaye David Gosal Bernhard Frank Uazman Alam |
| author_sort | Jamie Burgess |
| collection | DOAJ |
| description | Abstract Introduction Painful idiopathic distal sensory polyneuropathy (IDSP) and fibromyalgia syndrome (FMS) are cryptogenic chronic pain syndromes. The contribution of small fibre pathology (SFP) in FMS remains controversial. This study aims to quantify small nerve pathology in participants with IDSP and FMS and identify relationships of SFP with sensory phenotypes. Methods In this study, 73 individuals (FMS: 25, IDSP: 23, healthy volunteers: 25) underwent comprehensive assessment, including neurological exams, questionnaires, sensory tests, and corneal confocal microscopy. Results IDSP participants displayed lower wind-up ratio (WUR) relative to FMS (p < 0.001), loss of function to thermal and mechanical stimuli and elevated neuropathy disability scores compared to FMS and healthy volunteers (all p < 0.001). FMS participants demonstrated gain of function to heat and blunt pressure pain responses relative to IDSP, and healthy volunteers (heat: p = 0.002 and p = 0.003; pressure: both p < 0.001) and WUR (both p < 0.001). FMS participants exhibited reduced corneal nerve fibre density (p = 0.02), while IDSP participants had lower global corneal nerve measures (density, branch density, and length) relative to healthy volunteers (all p < 0.001). Utilising corneal nerve fibre length, SFP was demonstrated in 66.6% of participants (FMS: 13/25; IDSP: 22/23). Conclusion Participants with SFP, in both FMS and IDSP, reported symptoms indicative of small nerve fibre disease. Although distinctions in pain distributions are evident between individuals with FMS and IDSP, over 50% of participants between the two conditions displayed both a loss and gain of thermal and mechanical function suggestive of shared mechanisms. However, sensory phenotypes were associated with the presence of SFP in IDSP but not in FMS. |
| format | Article |
| id | doaj-art-ee9fe44cd7704dc5adc0a5c4ccfbe1f5 |
| institution | Kabale University |
| issn | 2193-8237 2193-651X |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Pain and Therapy |
| spelling | doaj-art-ee9fe44cd7704dc5adc0a5c4ccfbe1f52024-11-10T12:05:47ZengAdis, Springer HealthcarePain and Therapy2193-82372193-651X2024-09-011361541155810.1007/s40122-024-00646-xIdiopathic Distal Sensory Polyneuropathy and Fibromyalgia Syndrome: A Comparative Phenotyping StudyJamie Burgess0Anne Marshall1Leandros Rapteas2David Riley3Kohei Matsumoto4Cheng Boon5Alia Alchawaf6Maryam Ferdousi7Rayaz A. Malik8Andrew Marshall9Stephen Kaye10David Gosal11Bernhard Frank12Uazman Alam13Institute of Life Course and Medical Sciences, University of LiverpoolInstitute of Life Course and Medical Sciences, University of LiverpoolInstitute of Life Course and Medical Sciences, University of LiverpoolInstitute of Life Course and Medical Sciences, University of LiverpoolLiverpool University Hospitals NHS Foundation Trust, Aintree HospitalDepartment of Clinical Oncology, The Royal Wolverhampton NHS TrustClatterbridge Cancer CentreFaculty of Biology, Medicine and Health, University of ManchesterDivision of Medicine, Qatar Foundation, Weill Cornell Medicine-QatarInstitute of Life Course and Medical Sciences, University of LiverpoolDepartment of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of LiverpoolDepartment of Neurology, Salford Royal NHS Foundation TrustInstitute of Life Course and Medical Sciences, University of LiverpoolInstitute of Life Course and Medical Sciences, University of LiverpoolAbstract Introduction Painful idiopathic distal sensory polyneuropathy (IDSP) and fibromyalgia syndrome (FMS) are cryptogenic chronic pain syndromes. The contribution of small fibre pathology (SFP) in FMS remains controversial. This study aims to quantify small nerve pathology in participants with IDSP and FMS and identify relationships of SFP with sensory phenotypes. Methods In this study, 73 individuals (FMS: 25, IDSP: 23, healthy volunteers: 25) underwent comprehensive assessment, including neurological exams, questionnaires, sensory tests, and corneal confocal microscopy. Results IDSP participants displayed lower wind-up ratio (WUR) relative to FMS (p < 0.001), loss of function to thermal and mechanical stimuli and elevated neuropathy disability scores compared to FMS and healthy volunteers (all p < 0.001). FMS participants demonstrated gain of function to heat and blunt pressure pain responses relative to IDSP, and healthy volunteers (heat: p = 0.002 and p = 0.003; pressure: both p < 0.001) and WUR (both p < 0.001). FMS participants exhibited reduced corneal nerve fibre density (p = 0.02), while IDSP participants had lower global corneal nerve measures (density, branch density, and length) relative to healthy volunteers (all p < 0.001). Utilising corneal nerve fibre length, SFP was demonstrated in 66.6% of participants (FMS: 13/25; IDSP: 22/23). Conclusion Participants with SFP, in both FMS and IDSP, reported symptoms indicative of small nerve fibre disease. Although distinctions in pain distributions are evident between individuals with FMS and IDSP, over 50% of participants between the two conditions displayed both a loss and gain of thermal and mechanical function suggestive of shared mechanisms. However, sensory phenotypes were associated with the presence of SFP in IDSP but not in FMS.https://doi.org/10.1007/s40122-024-00646-xIdiopathic distal sensory polyneuropathyFibromyalgia syndromeSmall fibreCorneal confocal microscopyQuantitative sensory testingNeuropathic pain |
| spellingShingle | Jamie Burgess Anne Marshall Leandros Rapteas David Riley Kohei Matsumoto Cheng Boon Alia Alchawaf Maryam Ferdousi Rayaz A. Malik Andrew Marshall Stephen Kaye David Gosal Bernhard Frank Uazman Alam Idiopathic Distal Sensory Polyneuropathy and Fibromyalgia Syndrome: A Comparative Phenotyping Study Pain and Therapy Idiopathic distal sensory polyneuropathy Fibromyalgia syndrome Small fibre Corneal confocal microscopy Quantitative sensory testing Neuropathic pain |
| title | Idiopathic Distal Sensory Polyneuropathy and Fibromyalgia Syndrome: A Comparative Phenotyping Study |
| title_full | Idiopathic Distal Sensory Polyneuropathy and Fibromyalgia Syndrome: A Comparative Phenotyping Study |
| title_fullStr | Idiopathic Distal Sensory Polyneuropathy and Fibromyalgia Syndrome: A Comparative Phenotyping Study |
| title_full_unstemmed | Idiopathic Distal Sensory Polyneuropathy and Fibromyalgia Syndrome: A Comparative Phenotyping Study |
| title_short | Idiopathic Distal Sensory Polyneuropathy and Fibromyalgia Syndrome: A Comparative Phenotyping Study |
| title_sort | idiopathic distal sensory polyneuropathy and fibromyalgia syndrome a comparative phenotyping study |
| topic | Idiopathic distal sensory polyneuropathy Fibromyalgia syndrome Small fibre Corneal confocal microscopy Quantitative sensory testing Neuropathic pain |
| url | https://doi.org/10.1007/s40122-024-00646-x |
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