Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration
Background: The ultimate goal of tissue engineering is to reproduce functional alveolar∖Periodontal complex. This study aimed to asses micro- and nano-formulated crystalline calcium sulfate as possible treatment of intrabony defect utilizing an autologous Platelet rich fibrin scaffold. Subjects: and...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426820301561 |
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| author | Abdulkarem A. Mohammed Amira M. Elsherbini Fatma M. Ibrahim Samah M. El-Meadawy Jilan M. Youssef |
| author_facet | Abdulkarem A. Mohammed Amira M. Elsherbini Fatma M. Ibrahim Samah M. El-Meadawy Jilan M. Youssef |
| author_sort | Abdulkarem A. Mohammed |
| collection | DOAJ |
| description | Background: The ultimate goal of tissue engineering is to reproduce functional alveolar∖Periodontal complex. This study aimed to asses micro- and nano-formulated crystalline calcium sulfate as possible treatment of intrabony defect utilizing an autologous Platelet rich fibrin scaffold. Subjects: and Methods: An experimental prospective split mouth design using eight healthy mongrel dog’s was conducted. After two months of extracting the first premolar, bilateral intrabony defects were created mesial to the mandibular second premolar. One side was grafted by nanocrystalline calcium sulfate, while, the opposite side was grafted with microcrystalline calcium sulfate graft. Dogs were randomly euthanized after one month (group I) and 3 months (group II). The primary outcomes were the histological changes of new bone formation in hematoxylin and eosin and Masson trichrome stains, while histomorphometric and radiographic analysis were the secondary outcome followed by statistical analysis (P value was set at .05). Results: There was a significant increase in the percentage of bone formation in relation to defect height in nanocrystalline compared to microcrystalline form after one month and three months in both histological (p-values of <0.0001) and radiographic results (p-values of <0.0001). Conclusion: Nanocrystalline calcium sulfate presented a significant enhanced periodontal regeneration compared to the microcrystalline form. |
| format | Article |
| id | doaj-art-ee915a01d54e4bfe817ddd9ab2925f8e |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-ee915a01d54e4bfe817ddd9ab2925f8e2024-11-23T06:28:27ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682021-01-011114752Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regenerationAbdulkarem A. Mohammed0Amira M. Elsherbini1Fatma M. Ibrahim2Samah M. El-Meadawy3Jilan M. Youssef4Oral Medicine and Periodontology, Faculty of Dentistry, Thamar University, Yemen; Oral Medicine and Periodontology, Faculty of Dentistry, Mansoura University, EgyptOral Biology, Faculty of Dentistry, Mansoura University, Egypt; Corresponding author. Lecturer of Oral Biology, Faculty of Dentistry, Mansoura University, 35511, 25 El Gomhouria St, Dakahlia Governorate, Egypt.Oral Biology, Faculty of Dentistry, Mansoura University, EgyptOral Medicine and Periodontology, Faculty of Dentistry, Mansoura University, EgyptOral Medicine and Periodontology, Faculty of Dentistry, Mansoura University, EgyptBackground: The ultimate goal of tissue engineering is to reproduce functional alveolar∖Periodontal complex. This study aimed to asses micro- and nano-formulated crystalline calcium sulfate as possible treatment of intrabony defect utilizing an autologous Platelet rich fibrin scaffold. Subjects: and Methods: An experimental prospective split mouth design using eight healthy mongrel dog’s was conducted. After two months of extracting the first premolar, bilateral intrabony defects were created mesial to the mandibular second premolar. One side was grafted by nanocrystalline calcium sulfate, while, the opposite side was grafted with microcrystalline calcium sulfate graft. Dogs were randomly euthanized after one month (group I) and 3 months (group II). The primary outcomes were the histological changes of new bone formation in hematoxylin and eosin and Masson trichrome stains, while histomorphometric and radiographic analysis were the secondary outcome followed by statistical analysis (P value was set at .05). Results: There was a significant increase in the percentage of bone formation in relation to defect height in nanocrystalline compared to microcrystalline form after one month and three months in both histological (p-values of <0.0001) and radiographic results (p-values of <0.0001). Conclusion: Nanocrystalline calcium sulfate presented a significant enhanced periodontal regeneration compared to the microcrystalline form.http://www.sciencedirect.com/science/article/pii/S2212426820301561Platelet rich fibrinMicrocrystalline calcium sulfateNanocrystalline calcium sulfatePeriodontal defectOne wall intrabony defect |
| spellingShingle | Abdulkarem A. Mohammed Amira M. Elsherbini Fatma M. Ibrahim Samah M. El-Meadawy Jilan M. Youssef Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration Journal of Oral Biology and Craniofacial Research Platelet rich fibrin Microcrystalline calcium sulfate Nanocrystalline calcium sulfate Periodontal defect One wall intrabony defect |
| title | Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration |
| title_full | Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration |
| title_fullStr | Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration |
| title_full_unstemmed | Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration |
| title_short | Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration |
| title_sort | biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration |
| topic | Platelet rich fibrin Microcrystalline calcium sulfate Nanocrystalline calcium sulfate Periodontal defect One wall intrabony defect |
| url | http://www.sciencedirect.com/science/article/pii/S2212426820301561 |
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