Artificial Heart Valve Scaffold Based on Electrospun PCL/PU Three-Layer Composite Fibers
Abnormal heart valve function is a major cause of heart disease and is often associated with high rates of morbidity and mortality from heart disease. Focusing on the field of valve replacement, tissue-engineered heart valves are becoming popular and attracting more attention. In this work, an artif...
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MDPI AG
2024-12-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/14/24/12001 |
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| author | Xu Gao Zhong Liu Zhiwei Zhang Yuan Gao Jun Zhang Yunze Long |
| author_facet | Xu Gao Zhong Liu Zhiwei Zhang Yuan Gao Jun Zhang Yunze Long |
| author_sort | Xu Gao |
| collection | DOAJ |
| description | Abnormal heart valve function is a major cause of heart disease and is often associated with high rates of morbidity and mortality from heart disease. Focusing on the field of valve replacement, tissue-engineered heart valves are becoming popular and attracting more attention. In this work, an artificial heart valve scaffold based on polycaprolactone/polyurethane (PCL/PU) three-layer composite fibers was prepared by 3D printing and electrospinning, including an inner PCL layer, a middle PCL/PU layer, and an outer PCL layer. The obtained valve scaffold had strong circumferential mechanical properties when PCL/PU = 1:2, and its elastic modulus was 14.7 MPa, similar to that of natural valve. The heart valve scaffold had good cytocompatibility, and the final cell survival rate was 99.8% after 14 days of cell culture. The layered structure makes the artificial heart valve more similar to the natural structure of the mammalian heart, which is conducive to cell proliferation and differentiation, and provides a reference solution for interventional treatment of heart valves. |
| format | Article |
| id | doaj-art-ee8bd6f013f34f4eacd62077488c2098 |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-ee8bd6f013f34f4eacd62077488c20982024-12-27T14:09:03ZengMDPI AGApplied Sciences2076-34172024-12-0114241200110.3390/app142412001Artificial Heart Valve Scaffold Based on Electrospun PCL/PU Three-Layer Composite FibersXu Gao0Zhong Liu1Zhiwei Zhang2Yuan Gao3Jun Zhang4Yunze Long5Shandong Key Laboratory of Medical and Health Textile Materials, Innovation Institute for Advanced Nanofibers, College of Physics, Qingdao University, Qingdao 266071, ChinaShandong Key Laboratory of Medical and Health Textile Materials, Innovation Institute for Advanced Nanofibers, College of Physics, Qingdao University, Qingdao 266071, ChinaShandong Key Laboratory of Medical and Health Textile Materials, Innovation Institute for Advanced Nanofibers, College of Physics, Qingdao University, Qingdao 266071, ChinaShandong Key Laboratory of Medical and Health Textile Materials, Innovation Institute for Advanced Nanofibers, College of Physics, Qingdao University, Qingdao 266071, ChinaShandong Key Laboratory of Medical and Health Textile Materials, Innovation Institute for Advanced Nanofibers, College of Physics, Qingdao University, Qingdao 266071, ChinaShandong Key Laboratory of Medical and Health Textile Materials, Innovation Institute for Advanced Nanofibers, College of Physics, Qingdao University, Qingdao 266071, ChinaAbnormal heart valve function is a major cause of heart disease and is often associated with high rates of morbidity and mortality from heart disease. Focusing on the field of valve replacement, tissue-engineered heart valves are becoming popular and attracting more attention. In this work, an artificial heart valve scaffold based on polycaprolactone/polyurethane (PCL/PU) three-layer composite fibers was prepared by 3D printing and electrospinning, including an inner PCL layer, a middle PCL/PU layer, and an outer PCL layer. The obtained valve scaffold had strong circumferential mechanical properties when PCL/PU = 1:2, and its elastic modulus was 14.7 MPa, similar to that of natural valve. The heart valve scaffold had good cytocompatibility, and the final cell survival rate was 99.8% after 14 days of cell culture. The layered structure makes the artificial heart valve more similar to the natural structure of the mammalian heart, which is conducive to cell proliferation and differentiation, and provides a reference solution for interventional treatment of heart valves.https://www.mdpi.com/2076-3417/14/24/12001PCL-PUlayered structureelectrospinningartificial heart valve |
| spellingShingle | Xu Gao Zhong Liu Zhiwei Zhang Yuan Gao Jun Zhang Yunze Long Artificial Heart Valve Scaffold Based on Electrospun PCL/PU Three-Layer Composite Fibers Applied Sciences PCL-PU layered structure electrospinning artificial heart valve |
| title | Artificial Heart Valve Scaffold Based on Electrospun PCL/PU Three-Layer Composite Fibers |
| title_full | Artificial Heart Valve Scaffold Based on Electrospun PCL/PU Three-Layer Composite Fibers |
| title_fullStr | Artificial Heart Valve Scaffold Based on Electrospun PCL/PU Three-Layer Composite Fibers |
| title_full_unstemmed | Artificial Heart Valve Scaffold Based on Electrospun PCL/PU Three-Layer Composite Fibers |
| title_short | Artificial Heart Valve Scaffold Based on Electrospun PCL/PU Three-Layer Composite Fibers |
| title_sort | artificial heart valve scaffold based on electrospun pcl pu three layer composite fibers |
| topic | PCL-PU layered structure electrospinning artificial heart valve |
| url | https://www.mdpi.com/2076-3417/14/24/12001 |
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