Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma

Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma

Summary: Activating mutations in the epidermal growth factor receptor (EGFR) promote ligand-independent signaling; however, the mechanisms involved are poorly defined, and it is unknown whether this generates specific vulnerabilities. We previously observed robust expression of protein kinase Cα (PK...

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Bibliographic Details
Main Authors: Mojtaba Sadeghi, Mohamed F. Salama, Sam B. Chiappone, Amy Huang, Andrew E. Resnick, Manoj Kandpal, Christopher J. Clarke, John D. Haley, Ramana V. Davuluri, Yusuf A. Hannun
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724013779
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