C60 fullerene improves the recovery of biomechanical parameters of muscle soleus contraction in rats after chronic alcoholization
Background: Recovery of biomechanical parameters of contraction of muscles damaged by alcoholic myopathy is a rather complex and long-term process. Therefore, the search for effective therapeutic means for its acceleration is an extremely urgent task in biomedicine. Aim of work: The effect of C60...
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V.N. Karazin Kharkiv National University
2024-08-01
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| Series: | Біофізичний вісник |
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| Online Access: | https://periodicals.karazin.ua/biophysvisnyk/article/view/23061 |
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| author | Д. М. Ноздренко В. Нан Т. Ю. Матвієнко К. І. Богуцька Т. Я. Шевчук В. П. Берест Ю. І. Прилуцький |
| author_facet | Д. М. Ноздренко В. Нан Т. Ю. Матвієнко К. І. Богуцька Т. Я. Шевчук В. П. Берест Ю. І. Прилуцький |
| author_sort | Д. М. Ноздренко |
| collection | DOAJ |
| description | Background: Recovery of biomechanical parameters of contraction of muscles damaged by alcoholic myopathy is a rather complex and long-term process. Therefore, the search for effective therapeutic means for its acceleration is an extremely urgent task in biomedicine.
Aim of work: The effect of C60 fullerene aqueous solution (C60FAS) on the dynamics of skeletal muscle contraction in rats after 9 months of chronic alcoholization and 2 months after cessation of alcohol consumption was investigated.
Materials and Methods: When analyzing the miotic response using tensometry, such biomechanical parameters as the time of reduction of the muscle force response by 50% from the initial value, the values of the contraction force and the impulse of the muscle force were evaluated.
Results: It has been shown that animals orally administered alcohol and C60FAS (daily dose of 1 mg/kg) together (scheme II) during the experiment showed an increase in muscle force response by 40–45±2% compared with the group of alcoholized animals and by 12–15±1% compared with the group of rats administered C60FAS 1 h after alcohol ingestion (scheme I). The positive effect of C60FAS administration according to scheme II and scheme I was 34±2% and 10±1%, respectively, compared with the group of alcoholized animals in the case of recording the time of reduction of the muscle force response by 50% of the initial value. After 2 months of rehabilitation, the level of minimum muscle contraction force when using C60FAS in both schemes differed by about 15±1% compared to the group of alcoholized animals, and the time of reduction of the force response by 50% was not significantly recorded. Finally, the use of C60FAS revealed a significant increase in the magnitude of the muscle force impulse: up to 86±4% (scheme I) and almost to control values — 94±2% (scheme II).
Conclusions: The obtained results indicate the prospects of using C60FAS to restore the biomechanical parameters of skeletal muscle contraction during long-term development of alcoholic myopathy. |
| format | Article |
| id | doaj-art-ee6040a383d948e2a1eb69ecdf5b9c22 |
| institution | Kabale University |
| issn | 2075-3810 2075-3829 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | V.N. Karazin Kharkiv National University |
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| series | Біофізичний вісник |
| spelling | doaj-art-ee6040a383d948e2a1eb69ecdf5b9c222025-01-06T15:24:52ZengV.N. Karazin Kharkiv National UniversityБіофізичний вісник2075-38102075-38292024-08-0151647410.26565/2075-3810-2024-51-0523061C60 fullerene improves the recovery of biomechanical parameters of muscle soleus contraction in rats after chronic alcoholizationД. М. Ноздренко0В. Нан1Т. Ю. Матвієнко2К. І. Богуцька3Т. Я. Шевчук4В. П. Берест5Ю. І. Прилуцький6Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, 01601, Ukraine Lesya Ukrainka Volyn National University, 13 Volya Ave., Lutsk, 43025, UkraineTaras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, 01601, Ukraine Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, 01601, Lesya Ukrainka Volyn National University, 13 Volya Ave., Lutsk, 43025, UkraineV. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61022, Ukraine Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska Str., Kyiv, 01601, UkraineBackground: Recovery of biomechanical parameters of contraction of muscles damaged by alcoholic myopathy is a rather complex and long-term process. Therefore, the search for effective therapeutic means for its acceleration is an extremely urgent task in biomedicine. Aim of work: The effect of C60 fullerene aqueous solution (C60FAS) on the dynamics of skeletal muscle contraction in rats after 9 months of chronic alcoholization and 2 months after cessation of alcohol consumption was investigated. Materials and Methods: When analyzing the miotic response using tensometry, such biomechanical parameters as the time of reduction of the muscle force response by 50% from the initial value, the values of the contraction force and the impulse of the muscle force were evaluated. Results: It has been shown that animals orally administered alcohol and C60FAS (daily dose of 1 mg/kg) together (scheme II) during the experiment showed an increase in muscle force response by 40–45±2% compared with the group of alcoholized animals and by 12–15±1% compared with the group of rats administered C60FAS 1 h after alcohol ingestion (scheme I). The positive effect of C60FAS administration according to scheme II and scheme I was 34±2% and 10±1%, respectively, compared with the group of alcoholized animals in the case of recording the time of reduction of the muscle force response by 50% of the initial value. After 2 months of rehabilitation, the level of minimum muscle contraction force when using C60FAS in both schemes differed by about 15±1% compared to the group of alcoholized animals, and the time of reduction of the force response by 50% was not significantly recorded. Finally, the use of C60FAS revealed a significant increase in the magnitude of the muscle force impulse: up to 86±4% (scheme I) and almost to control values — 94±2% (scheme II). Conclusions: The obtained results indicate the prospects of using C60FAS to restore the biomechanical parameters of skeletal muscle contraction during long-term development of alcoholic myopathy.https://periodicals.karazin.ua/biophysvisnyk/article/view/23061c 60 fullerenemuscle soleusalcoholic myopathyrecoverybiomechanical parameters of skeletal muscle contration |
| spellingShingle | Д. М. Ноздренко В. Нан Т. Ю. Матвієнко К. І. Богуцька Т. Я. Шевчук В. П. Берест Ю. І. Прилуцький C60 fullerene improves the recovery of biomechanical parameters of muscle soleus contraction in rats after chronic alcoholization Біофізичний вісник c 60 fullerene muscle soleus alcoholic myopathy recovery biomechanical parameters of skeletal muscle contration |
| title | C60 fullerene improves the recovery of biomechanical parameters of muscle soleus contraction in rats after chronic alcoholization |
| title_full | C60 fullerene improves the recovery of biomechanical parameters of muscle soleus contraction in rats after chronic alcoholization |
| title_fullStr | C60 fullerene improves the recovery of biomechanical parameters of muscle soleus contraction in rats after chronic alcoholization |
| title_full_unstemmed | C60 fullerene improves the recovery of biomechanical parameters of muscle soleus contraction in rats after chronic alcoholization |
| title_short | C60 fullerene improves the recovery of biomechanical parameters of muscle soleus contraction in rats after chronic alcoholization |
| title_sort | c60 fullerene improves the recovery of biomechanical parameters of muscle soleus contraction in rats after chronic alcoholization |
| topic | c 60 fullerene muscle soleus alcoholic myopathy recovery biomechanical parameters of skeletal muscle contration |
| url | https://periodicals.karazin.ua/biophysvisnyk/article/view/23061 |
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