Cell Membrane-Camouflaged Nanoparticles: A Promising Biomimetic Platform for Tumor Therapy
Over the past several decades, nanoparticles (NPs) have attracted considerable attention for anti-tumor treatment. However, exogenous NPs directly exposed to the physiological environment are easily recognized as foreign substances and rapidly eliminated by the immune system. Cell membrane camouflag...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Journal of Chemical Engineering of Japan |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/00219592.2024.2434611 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841526689779154944 |
|---|---|
| author | Chengliang Lyu Wenjin Wang Yuan Yang Peilin Guo Feng Li Wei Wei |
| author_facet | Chengliang Lyu Wenjin Wang Yuan Yang Peilin Guo Feng Li Wei Wei |
| author_sort | Chengliang Lyu |
| collection | DOAJ |
| description | Over the past several decades, nanoparticles (NPs) have attracted considerable attention for anti-tumor treatment. However, exogenous NPs directly exposed to the physiological environment are easily recognized as foreign substances and rapidly eliminated by the immune system. Cell membrane camouflaging can provide “stealth” ability to NPs for avoiding recognition and elimination by the immune system, and endows NPs with diverse functionalities via inheriting the functions of parent cells, representing a facile top-down approach for multi-functionalization. In this review, we discuss the unique biomedical tasks performed by cell membrane-camouflaged NPs for tumor therapy in term of circulation, targeting, and immunity. In addition to the intrinsic functions derived from the cell membrane camouflaging, we introduce further improvements in cell membrane-camouflaged NPs via additional functionalities and combinations with novel technologies. Finally, we highlight the current challenges and prospects of these cell membrane camouflaging therapeutics that will contribute to the development. |
| format | Article |
| id | doaj-art-ee35e970574345d5af481495d4895fba |
| institution | Kabale University |
| issn | 0021-9592 1881-1299 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Chemical Engineering of Japan |
| spelling | doaj-art-ee35e970574345d5af481495d4895fba2025-01-16T15:12:05ZengTaylor & Francis GroupJournal of Chemical Engineering of Japan0021-95921881-12992025-12-0158110.1080/00219592.2024.2434611Cell Membrane-Camouflaged Nanoparticles: A Promising Biomimetic Platform for Tumor TherapyChengliang Lyu0Wenjin Wang1Yuan Yang2Peilin Guo3Feng Li4Wei Wei5State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, ChinaOver the past several decades, nanoparticles (NPs) have attracted considerable attention for anti-tumor treatment. However, exogenous NPs directly exposed to the physiological environment are easily recognized as foreign substances and rapidly eliminated by the immune system. Cell membrane camouflaging can provide “stealth” ability to NPs for avoiding recognition and elimination by the immune system, and endows NPs with diverse functionalities via inheriting the functions of parent cells, representing a facile top-down approach for multi-functionalization. In this review, we discuss the unique biomedical tasks performed by cell membrane-camouflaged NPs for tumor therapy in term of circulation, targeting, and immunity. In addition to the intrinsic functions derived from the cell membrane camouflaging, we introduce further improvements in cell membrane-camouflaged NPs via additional functionalities and combinations with novel technologies. Finally, we highlight the current challenges and prospects of these cell membrane camouflaging therapeutics that will contribute to the development.https://www.tandfonline.com/doi/10.1080/00219592.2024.2434611Cell membrane camouflagingBiomimetic strategyMulti-functionalizationBiomedical tasksAnti-tumor application |
| spellingShingle | Chengliang Lyu Wenjin Wang Yuan Yang Peilin Guo Feng Li Wei Wei Cell Membrane-Camouflaged Nanoparticles: A Promising Biomimetic Platform for Tumor Therapy Journal of Chemical Engineering of Japan Cell membrane camouflaging Biomimetic strategy Multi-functionalization Biomedical tasks Anti-tumor application |
| title | Cell Membrane-Camouflaged Nanoparticles: A Promising Biomimetic Platform for Tumor Therapy |
| title_full | Cell Membrane-Camouflaged Nanoparticles: A Promising Biomimetic Platform for Tumor Therapy |
| title_fullStr | Cell Membrane-Camouflaged Nanoparticles: A Promising Biomimetic Platform for Tumor Therapy |
| title_full_unstemmed | Cell Membrane-Camouflaged Nanoparticles: A Promising Biomimetic Platform for Tumor Therapy |
| title_short | Cell Membrane-Camouflaged Nanoparticles: A Promising Biomimetic Platform for Tumor Therapy |
| title_sort | cell membrane camouflaged nanoparticles a promising biomimetic platform for tumor therapy |
| topic | Cell membrane camouflaging Biomimetic strategy Multi-functionalization Biomedical tasks Anti-tumor application |
| url | https://www.tandfonline.com/doi/10.1080/00219592.2024.2434611 |
| work_keys_str_mv | AT chenglianglyu cellmembranecamouflagednanoparticlesapromisingbiomimeticplatformfortumortherapy AT wenjinwang cellmembranecamouflagednanoparticlesapromisingbiomimeticplatformfortumortherapy AT yuanyang cellmembranecamouflagednanoparticlesapromisingbiomimeticplatformfortumortherapy AT peilinguo cellmembranecamouflagednanoparticlesapromisingbiomimeticplatformfortumortherapy AT fengli cellmembranecamouflagednanoparticlesapromisingbiomimeticplatformfortumortherapy AT weiwei cellmembranecamouflagednanoparticlesapromisingbiomimeticplatformfortumortherapy |