Impaired Vigilance in Patients with Narcolepsy Type 1: A Psychomotor Vigilance Task Study
Jiaqin Yu,1 Yuyan Zhou,1 Xiao Han,2 Zongshan Li,3 Feiyan Chen,2 Lisan Zhang4 1School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, People’s Republic of China; 2Bio-X Laboratory, School of Physics, Zhejiang University, Hangzhou, 310027, People’s Republic of China; 3Department of Neuro...
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2024-12-01
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| author | Yu J Zhou Y Han X Li Z Chen F Zhang L |
| author_facet | Yu J Zhou Y Han X Li Z Chen F Zhang L |
| author_sort | Yu J |
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| description | Jiaqin Yu,1 Yuyan Zhou,1 Xiao Han,2 Zongshan Li,3 Feiyan Chen,2 Lisan Zhang4 1School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, People’s Republic of China; 2Bio-X Laboratory, School of Physics, Zhejiang University, Hangzhou, 310027, People’s Republic of China; 3Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People’s Republic of China; 4Department of Neurology and Center for Sleep Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence: Lisan Zhang, Department of Neurology and Center for Sleep Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, Email zls09@zju.edu.cn Feiyan Chen, Bio-X Laboratory, School of Physics, Zhejiang University, Hangzhou, 310027, People’s Republic of China, Email chenfy@zju.edu.cnPurpose: The psychomotor vigilance task (PVT) is one of the main methods to measure sustained vigilance/attention in sleep research. Vigilance is the main factor affecting daytime function in patients with narcolepsy type 1 (NT1). We aimed to quantify the negative effects of sleep–wake disorders on vigilance and investigate potential neural mechanisms.Patients and Methods: We compared data from 42 patients and 31 healthy controls, including sociodemographics, nighttime sleep quality (Pittsburgh Sleep Quality Index, PSQI), sleepiness (Epworth Sleepiness Scale, ESS), cognitive abilities (Montreal Cognitive Assessment, MoCA), emotional control (Barratt Impulsiveness Scale-11, BIS-11), depressive symptoms (Patient Health Questionnaire-9, PHQ-9), and PVT performance. PVT outcomes analyzed included number of lapses, reaction time (RT), variability in RT, and the slowest and fastest 10% of RTs. All patients were diagnosed with NT1 based on The International Classification of Sleep Disorders-Third Edition.Results: Patients with NT1 had a significantly higher body mass index and longer duration of education than healthy controls. The patients also had a greater tendency for daytime sleepiness and poorer nighttime sleep quality, higher depression and impulsiveness scores, and more severe cognitive dysfunction. PVT performance was better in the healthy controls than in patients with NT1. We also noticed that emotional changes and the proportion of rapid eye movement sleep at night are related to PVT performance.Conclusion: More severe sleepiness and an increased emotional burden could underlie the arousal and vigilance deficits seen in patients with NT1. We speculate that impaired vigilance in patients with NT1 is associated with abnormal brain function caused by a resource allocation imbalance related to hypothalamic orexin neuron damage, sleep inertia may also have a slight impact on this. Future studies should delve into this topic more deeply.Keywords: narcolepsy, psychomotor vigilance task, vigilance, sleepiness, reaction time |
| format | Article |
| id | doaj-art-ee203e0d7df645a0aadaa9cc06d0df9b |
| institution | Kabale University |
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| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-ee203e0d7df645a0aadaa9cc06d0df9b2024-12-19T17:40:21ZengDove Medical PressNature and Science of Sleep1179-16082024-12-01Volume 162021202898310Impaired Vigilance in Patients with Narcolepsy Type 1: A Psychomotor Vigilance Task StudyYu JZhou YHan XLi ZChen FZhang LJiaqin Yu,1 Yuyan Zhou,1 Xiao Han,2 Zongshan Li,3 Feiyan Chen,2 Lisan Zhang4 1School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, People’s Republic of China; 2Bio-X Laboratory, School of Physics, Zhejiang University, Hangzhou, 310027, People’s Republic of China; 3Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People’s Republic of China; 4Department of Neurology and Center for Sleep Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence: Lisan Zhang, Department of Neurology and Center for Sleep Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, Email zls09@zju.edu.cn Feiyan Chen, Bio-X Laboratory, School of Physics, Zhejiang University, Hangzhou, 310027, People’s Republic of China, Email chenfy@zju.edu.cnPurpose: The psychomotor vigilance task (PVT) is one of the main methods to measure sustained vigilance/attention in sleep research. Vigilance is the main factor affecting daytime function in patients with narcolepsy type 1 (NT1). We aimed to quantify the negative effects of sleep–wake disorders on vigilance and investigate potential neural mechanisms.Patients and Methods: We compared data from 42 patients and 31 healthy controls, including sociodemographics, nighttime sleep quality (Pittsburgh Sleep Quality Index, PSQI), sleepiness (Epworth Sleepiness Scale, ESS), cognitive abilities (Montreal Cognitive Assessment, MoCA), emotional control (Barratt Impulsiveness Scale-11, BIS-11), depressive symptoms (Patient Health Questionnaire-9, PHQ-9), and PVT performance. PVT outcomes analyzed included number of lapses, reaction time (RT), variability in RT, and the slowest and fastest 10% of RTs. All patients were diagnosed with NT1 based on The International Classification of Sleep Disorders-Third Edition.Results: Patients with NT1 had a significantly higher body mass index and longer duration of education than healthy controls. The patients also had a greater tendency for daytime sleepiness and poorer nighttime sleep quality, higher depression and impulsiveness scores, and more severe cognitive dysfunction. PVT performance was better in the healthy controls than in patients with NT1. We also noticed that emotional changes and the proportion of rapid eye movement sleep at night are related to PVT performance.Conclusion: More severe sleepiness and an increased emotional burden could underlie the arousal and vigilance deficits seen in patients with NT1. We speculate that impaired vigilance in patients with NT1 is associated with abnormal brain function caused by a resource allocation imbalance related to hypothalamic orexin neuron damage, sleep inertia may also have a slight impact on this. Future studies should delve into this topic more deeply.Keywords: narcolepsy, psychomotor vigilance task, vigilance, sleepiness, reaction timehttps://www.dovepress.com/impaired-vigilance-in-patients-with-narcolepsy-type-1-a-psychomotor-vi-peer-reviewed-fulltext-article-NSSnarcolepsypsychomotor vigilance taskvigilancesleepinessreaction time |
| spellingShingle | Yu J Zhou Y Han X Li Z Chen F Zhang L Impaired Vigilance in Patients with Narcolepsy Type 1: A Psychomotor Vigilance Task Study Nature and Science of Sleep narcolepsy psychomotor vigilance task vigilance sleepiness reaction time |
| title | Impaired Vigilance in Patients with Narcolepsy Type 1: A Psychomotor Vigilance Task Study |
| title_full | Impaired Vigilance in Patients with Narcolepsy Type 1: A Psychomotor Vigilance Task Study |
| title_fullStr | Impaired Vigilance in Patients with Narcolepsy Type 1: A Psychomotor Vigilance Task Study |
| title_full_unstemmed | Impaired Vigilance in Patients with Narcolepsy Type 1: A Psychomotor Vigilance Task Study |
| title_short | Impaired Vigilance in Patients with Narcolepsy Type 1: A Psychomotor Vigilance Task Study |
| title_sort | impaired vigilance in patients with narcolepsy type 1 a psychomotor vigilance task study |
| topic | narcolepsy psychomotor vigilance task vigilance sleepiness reaction time |
| url | https://www.dovepress.com/impaired-vigilance-in-patients-with-narcolepsy-type-1-a-psychomotor-vi-peer-reviewed-fulltext-article-NSS |
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