Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology
Preclinical evidence suggests that voltage gradients can act as a kind of top-down master regulator during embryogenesis and orchestrate downstream molecular-genetic pathways during organ regeneration or repair. Moreover, electrical stimulation shifts response to injury toward regeneration instead o...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19336950.2023.2297605 |
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| author | Minas Sakellakis Sung Mi Yoon Jashan Reet Athanasios Chalkias |
| author_facet | Minas Sakellakis Sung Mi Yoon Jashan Reet Athanasios Chalkias |
| author_sort | Minas Sakellakis |
| collection | DOAJ |
| description | Preclinical evidence suggests that voltage gradients can act as a kind of top-down master regulator during embryogenesis and orchestrate downstream molecular-genetic pathways during organ regeneration or repair. Moreover, electrical stimulation shifts response to injury toward regeneration instead of healing or scarring. Cancer and embryogenesis not only share common phenotypical features but also commonly upregulated molecular pathways. Voltage-gated ion channel activity is directly or indirectly linked to the pathogenesis of cancer hallmarks, while experimental and clinical studies suggest that their modulation, e.g., by anesthetic agents, may exert antitumor effects. A large recent clinical trial served as a proof-of-principle for the benefit of preoperative use of topical sodium channel blockade as a potential anticancer strategy against early human breast cancers. Regardless of whether ion channel aberrations are primary or secondary cancer drivers, understanding the functional consequences of these events may guide us toward the development of novel therapeutic approaches. |
| format | Article |
| id | doaj-art-ee174c9df1d04df082f79233bd8e18e6 |
| institution | Kabale University |
| issn | 1933-6950 1933-6969 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Channels |
| spelling | doaj-art-ee174c9df1d04df082f79233bd8e18e62024-12-09T07:27:27ZengTaylor & Francis GroupChannels1933-69501933-69692024-12-0118110.1080/19336950.2023.2297605Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncologyMinas Sakellakis0Sung Mi Yoon1Jashan Reet2Athanasios Chalkias3Department of Medicine, Jacobi North Central Bronx Hospital, Bronx, USADepartment of Medicine, Jacobi North Central Bronx Hospital, Bronx, USADepartment of Medicine, Jacobi North Central Bronx Hospital, Bronx, USAInstitute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAPreclinical evidence suggests that voltage gradients can act as a kind of top-down master regulator during embryogenesis and orchestrate downstream molecular-genetic pathways during organ regeneration or repair. Moreover, electrical stimulation shifts response to injury toward regeneration instead of healing or scarring. Cancer and embryogenesis not only share common phenotypical features but also commonly upregulated molecular pathways. Voltage-gated ion channel activity is directly or indirectly linked to the pathogenesis of cancer hallmarks, while experimental and clinical studies suggest that their modulation, e.g., by anesthetic agents, may exert antitumor effects. A large recent clinical trial served as a proof-of-principle for the benefit of preoperative use of topical sodium channel blockade as a potential anticancer strategy against early human breast cancers. Regardless of whether ion channel aberrations are primary or secondary cancer drivers, understanding the functional consequences of these events may guide us toward the development of novel therapeutic approaches.https://www.tandfonline.com/doi/10.1080/19336950.2023.2297605Ionchannelsregenerationcancertreatmenttranslational research |
| spellingShingle | Minas Sakellakis Sung Mi Yoon Jashan Reet Athanasios Chalkias Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology Channels Ion channels regeneration cancer treatment translational research |
| title | Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology |
| title_full | Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology |
| title_fullStr | Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology |
| title_full_unstemmed | Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology |
| title_short | Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology |
| title_sort | novel insights into voltage gated ion channels translational breakthroughs in medical oncology |
| topic | Ion channels regeneration cancer treatment translational research |
| url | https://www.tandfonline.com/doi/10.1080/19336950.2023.2297605 |
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