A reproducible rat model for predicting incisional hernia recurrence: insights for clinical translation

A reproducible rat model for predicting incisional hernia recurrence: insights for clinical translation

Abstract Incisional hernias are common complications following abdominal surgeries. This study aimed to develop a reproducible murine model of complex incisional hernia to better understand this condition and evaluate new therapeutic strategies. Fourteen male Wistar rats underwent laparotomy to indu...

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Main Authors: Eric Toshiyuki Nakamura, Francisco Tustumi, Marina Alessandra Pereira, Leonardo Cardili, Ana Paula Gárate, Bruno Cogliati, Venancio Avancini Ferreira Alves, Sandra Nassa Sampietre, Cinthia Lanchotte Ferreira, Giovanna Mattos Ferreira, Michelly Moreira Campos, Ulysses Ribeiro Junior, Luiz Augusto Carneiro D’Albuquerque, Flávio Henrique Ferreira Galvão
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Hernia
Incisional hernia
Abdominal wall defect
Animal model
Intra-abdominal pressure
Hernia recurrence
Online Access:https://doi.org/10.1038/s41598-025-05557-1
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