Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma

Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common as well as leading causes of mortality worldwide, and sorafenib is the first-line treatment in HCC patients. Unfortunately, drug resistance to sorafenib often develops. However, the underlying mechanism remains unclear. Her...

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Bibliographic Details
Main Authors: Xiangbo Huang, Nan Yi, Pengfei Zhu, Jian Gao, Jun Lv
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Biology Direct
Subjects:
Hepatocellular carcinoma
Sorafenib
Macrophage extracellular traps
ARHGDIG
IL4
PADI4
Online Access:https://doi.org/10.1186/s13062-024-00560-4
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