Molecular insights into the activation mechanism of GPR156 in maintaining auditory function

Molecular insights into the activation mechanism of GPR156 in maintaining auditory function

Abstract The class C orphan G-protein-coupled receptor (GPCR) GPR156, which lacks the large extracellular region, plays a pivotal role in auditory function through Gi2/3. Here, we firstly demonstrate that GPR156 with high constitutive activity is essential for maintaining auditory function, and furt...

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Main Authors: Xiangyu Ma, Li-Nan Chen, Menghui Liao, Liyan Zhang, Kun Xi, Jiamin Guo, Cangsong Shen, Dan-Dan Shen, Pengjun Cai, Qingya Shen, Jieyu Qi, Huibing Zhang, Shao-Kun Zang, Ying-Jun Dong, Luwei Miao, Jiao Qin, Su-Yu Ji, Yue Li, Jianfeng Liu, Chunyou Mao, Yan Zhang, Renjie Chai
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54681-5
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